International Journal of Contemporary Medicine

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A Prospective Study to Analyse the efficacy of Apraclonidine in Preventing Intraocular Pressure Rise After Neodymium: YAG (Nd-YAG) Laser Posterior Capsulotomy


Affiliations
1 Department of Pharmacology, Saraswathi Institute of Medical Sciences, Hapur, Ghaziabad, U.P., India
2 Department of Ophthalmology, Saraswathi Institute of Medical Sciences, Hapur, Ghaziabad, U.P., India
3 Demonstrator Pharmacology of Saraswathi Institute of Medical Sciences, Hapur, Ghaziabad, U.P., India
     

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Objective: To analyse the efficacy of (0.5%) apraclonidine in preventing the acute rise of intraocular pressure following Nd-YAG Laser posterior capsulotomy. Material and method: A prospective case controlled randomised study was performed in the department of ophthalmology of SIMS in collaboration of department of pharmacology. Result: A total 52 patients were divided in two groups. Half of the patients were given 0.5% topical apraclonidine 15 minutes before the procedure and immediately after the procedure and after 1 hr, 2hr, and 4hrs respectively. The other half were not given any IOP lowering drug.IOP was measured by tonometry. There was significant fall in IOP in test group patients. IOP in two groups 1hr after procedure was 13.08% rise in control and 6.40% fall in test group. Conclusion: Apraclonidine, a highly selective alpha2 adrenoceptor agonist effectively and safely lowers IOP spikes after laser treatment without causing significant side effects like bradycardia or hypotension.

Keywords

Apraclonidine, Intra-Ocularpressure(IOP), Aqueous-Humor, Nd-Yagcapsulotomy, Posterior Capsular Opacification(PCO), Cataract.
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  • Fankhauser F, Roussel P, Steffen J, Van der Zypen E, Chrenkova A. Clinical studies on the efficiency of high power laser radiation upon some structures of the anterior segment of the eye. First experiences of the treatment of some pathological conditions of the anterior segment of the human eye by means of a Q-switched laser system. Int Ophthalmol. 1981 May;3(3):129–139.

  • Terry AC, Stark WJ, Maumenee AE, Fagadau W. Neodymium-YAG laser for posterior capsulotomy. Am J Ophthalmol. 1983 Dec;96(6):716–72

  • Shrader CE, Belcher CD, 3rd, Thomas JV, Simmons RJ. Acute glaucoma following Nd: YAG laser membranotomy. Ophthalmic Surg. 1983 Dec;14(12):1015–1016.

  • Weinreb RN, Robin AL, Baerveldt G, Drake MV, Blumenthal M, Wilensky J. Flurbiprofen pretreatment in argon laser trabeculoplasty for primary open-angle glaucoma. Arch Ophthalmol. 1984 Nov;102(11):1629–1632.

  • Keates RH, Steinert RF, Puliafito CA, Maxwell SK. Long-term follow-up of Nd:YAG laser posterior capsulotomy. J Am Intraocul Implant Soc. 1984 Spring;10(2):164–168.

  • Parker WT, Clorfeine GS, Stocklin RD. Marked intraocular pressure rise following Nd:YAG laser capsulotomy. Ophthalmic Surg. 1984 Feb;15(2):103–104.

  • Slomovic AR, Parrish RK., 2nd Acute elevations of intraocular pressure following Nd:YAG laser posterior capsulotomy. Ophthalmology. 1985 Jul;92(7):973–976.

  • Richter CU, Arzeno G, Pappas HR, Arrigg CA, Wasson P, Steinert RF. Prevention of intraocular pressure elevation following neodymium-YAG laser posterior capsulotomy. Arch Ophthalmol. 1985 Jul;103(7):912–915.

  • Migliori ME, Beckman H, Channell MM. Intraocular pressure changes after neodymium- YAG laser capsulotomy in eyes pretreated with timolol. Arch Ophthalmol. 1987 Apr;105(4): 473–475.]

  • Brown SV, Thomas JV, Belcher CD, 3rd, Simmons RJ. Effect of pilocarpine in treatment of intraocular pressure elevation following neodymium: YAG laser posterior capsulotomy. Ophthalmology. 1985 Mar;92(3):354–359.]

  • Flohr MJ, Robin AL, Kelley JS. Early complications following Q-switched neodymium: YAG laser posterior capsulotomy. Ophthalmology. 1985 Mar;92(3):360–363Kraff MC, Sanders DR, Lieberman HL. Intraocular pressure and the corneal endothelium after neodymium-YAG laser posterior capsulotomy. Relative effects of aphakia and pseudophakia. Arch Ophthalmol. 1985 Apr;103(4):511–514.]

  • Vine AK. Ocular hypertension following Nd:YAG laser capsulotomy: a potentially blinding complication. Ophthalmic Surg. 1984 Apr;15(4):283–284.]

  • Robin AL, Pollack IP, deFaller JM. Effects of topical ALO 2145 (p-aminoclonidine hydrochloride) on the acute intraocular pressure rise after argon laser iridotomy. Arch Ophthalmol. 1987 Sep;105(9):1208–1211.

  • Robin AL, Pollack IP, House B, Enger C. Effects of ALO 2145 on intraocular pressure following argon laser trabeculoplasty. Arch Ophthalmol. 1987 May;105(5):646–650.]


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  • A Prospective Study to Analyse the efficacy of Apraclonidine in Preventing Intraocular Pressure Rise After Neodymium: YAG (Nd-YAG) Laser Posterior Capsulotomy

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Authors

Sunita Singh
Department of Pharmacology, Saraswathi Institute of Medical Sciences, Hapur, Ghaziabad, U.P., India
Vikrant Sharma
Department of Ophthalmology, Saraswathi Institute of Medical Sciences, Hapur, Ghaziabad, U.P., India
Vivek Singh
Demonstrator Pharmacology of Saraswathi Institute of Medical Sciences, Hapur, Ghaziabad, U.P., India

Abstract


Objective: To analyse the efficacy of (0.5%) apraclonidine in preventing the acute rise of intraocular pressure following Nd-YAG Laser posterior capsulotomy. Material and method: A prospective case controlled randomised study was performed in the department of ophthalmology of SIMS in collaboration of department of pharmacology. Result: A total 52 patients were divided in two groups. Half of the patients were given 0.5% topical apraclonidine 15 minutes before the procedure and immediately after the procedure and after 1 hr, 2hr, and 4hrs respectively. The other half were not given any IOP lowering drug.IOP was measured by tonometry. There was significant fall in IOP in test group patients. IOP in two groups 1hr after procedure was 13.08% rise in control and 6.40% fall in test group. Conclusion: Apraclonidine, a highly selective alpha2 adrenoceptor agonist effectively and safely lowers IOP spikes after laser treatment without causing significant side effects like bradycardia or hypotension.

Keywords


Apraclonidine, Intra-Ocularpressure(IOP), Aqueous-Humor, Nd-Yagcapsulotomy, Posterior Capsular Opacification(PCO), Cataract.

References