International Journal of Contemporary Medicine

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A Study of HIV and TB Co-infection in Relation to CD4 Count in Patients Visiting a Tertiary Care Centre


Affiliations
1 Department of Microbiology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India
2 Department of Microbiology, Kamineni Institute of Medical Sciences, Narketpally, Nalgonda District, Andhra Pradesh, India
     

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Background: The emergence of HIV infection has paved way for various opportunistic infections during the natural course of the disease. Tuberculosis is one of the commonest opportunistic infections and often the two infections are diagnosed concurrently. TB accelerates the progression of HIV infection leading to decline in CD4count. The present study was carried out to estimate CD4 count in HIV & TB co-infection.

Method: A retrospective analysis of confirmed HIV positive patients was carried out for a period of 1 year. TB diagnosis was done on the basis of clinical signs and symptoms, smear microscopy and chest radiography as per the RNTCP guidelines. The CD4count was done by flow cytometry. Chi square test was employed for analysis.

Results: The study population comprised of 101 confirmed HIV positive patients. Co-infection with TB was found in 14(13.86%), of which 10(18.18%) patients were male and 4(8.69%) were female. Of the 14 confirmed co-infection patients, the CD4count was 500 in 2(14.28%) patients. The CD4count in HIV positive patients without TB infection was 500 in 6 (6.89%) patients. There was statistically significant difference between HIV and TB co-infected patients and HIV infected patients with reference to proportion of patients with low CD4count (< 250) (P< 0.05)

Conclusion: Tuberculosis infection in HIV positive patients further declines the CD4count.


Keywords

Co-infection, CD4count.
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  • A Study of HIV and TB Co-infection in Relation to CD4 Count in Patients Visiting a Tertiary Care Centre

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Authors

N Girish
Department of Microbiology, Vydehi Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India
B Sreekanth
Department of Microbiology, Kamineni Institute of Medical Sciences, Narketpally, Nalgonda District, Andhra Pradesh, India
K Saileela
Department of Microbiology, Kamineni Institute of Medical Sciences, Narketpally, Nalgonda District, Andhra Pradesh, India

Abstract


Background: The emergence of HIV infection has paved way for various opportunistic infections during the natural course of the disease. Tuberculosis is one of the commonest opportunistic infections and often the two infections are diagnosed concurrently. TB accelerates the progression of HIV infection leading to decline in CD4count. The present study was carried out to estimate CD4 count in HIV & TB co-infection.

Method: A retrospective analysis of confirmed HIV positive patients was carried out for a period of 1 year. TB diagnosis was done on the basis of clinical signs and symptoms, smear microscopy and chest radiography as per the RNTCP guidelines. The CD4count was done by flow cytometry. Chi square test was employed for analysis.

Results: The study population comprised of 101 confirmed HIV positive patients. Co-infection with TB was found in 14(13.86%), of which 10(18.18%) patients were male and 4(8.69%) were female. Of the 14 confirmed co-infection patients, the CD4count was 500 in 2(14.28%) patients. The CD4count in HIV positive patients without TB infection was 500 in 6 (6.89%) patients. There was statistically significant difference between HIV and TB co-infected patients and HIV infected patients with reference to proportion of patients with low CD4count (< 250) (P< 0.05)

Conclusion: Tuberculosis infection in HIV positive patients further declines the CD4count.


Keywords


Co-infection, CD4count.

References