Indian Journal of Biotechnology & Biochemistry

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

A Comparative Study on of Lipid Profile of Smokers & Non-Smokers


Affiliations
1 Department of Biochemistry,AMC College, Bangalore, India
2 Department of Zoology,Meenakshi College, Madurai
3 Department of Biochemistry, KGF Dental College, Bangalore, India
     

   Subscribe/Renew Journal


A comparative study was made between smokers and non smokers of similar age in Hosur. The aim of the present study was to assess the association between cigarette smoke and the alteration in plasma concentration of lipid profile and to assess the risk factors for cardiovascular disease between smokers and nonsmokers as increase in lipids level may lead to cardiovascular disease. Fifty smokers and fifty non-smokers were enrolled for the study. Smokers had significantly higher of total cholesterol, triglyceride, very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) and significantly lower serum levels of high-density lipoprotein (HDL) in their serum. All the smoking-associated changes significantly increased in adult smokers. Prevalence of hypertension, hypercholesterolaemia, Hypertriglyceridaemia, hyperlipoproteinaemia was significantly greater in smokers as compared to nonsmokers.

Keywords

Smoking, Lipids, Lipoproteins, Risk Factors, Cardiovascular, Cholesterol, Hypertension, Hypercholesterolemia, Hypertriglyceridaemia
Subscription Login to verify subscription
User
Notifications
Font Size


  • Abbassi A, Maheri WA, Akhund IA, Ujjan ID, Farooq M .Effect of Chronic Cigarette Smoking on Lipid Profile. Pakistan Journal of Medical and Health Sciences, Vol 1, No 1 (2007).

  • Albers JJ, Bergelin RO, Adolphson JL, Wahl PW Population-based reference values for lecithin-cholesterol acyltransferase (LCAT). Atherosclerosis 43 (2- 3): 369-379, 1982.

  • Ramani AK, Sudhakar S. Nayak,. R. Aroorn and Kundaje GN. Effect of cigarette smoking on serum lipid, lipoprotein and apolipoprotein levels in hypertensives receiving β-adrenoreceptor blocking drugs.Volume 6, Number 1/January, 1991.

  • Jaleel A, Jaleel F, Majeed R and Alam E. Leptin and Blood Lipid Levels in Smokers and ex Smokers. World Applied Sciences Journal 2 (4): 348-352, 2007.

  • Aparici M, Fernández González AL, Alegría E. Somatometry and lipid profile in smokers. Modifications after smoking withdrawal. Med Clin (Barc). 2007 july 17; 99 (7):277-8. B: Clinical laboratory methods. St. Louis, C.V. Mosby Co, 9th ed., 1982.

  • Brischetto CS, Connor WE, Connor SL, MatarazzoJD. Plasma lipid and lipoprotein profiles of cigarette smokers from randomly selected families:enhancement of hyperlipidemia and depression ofhigh density lipoprotein. Am J Cardiol 1983; 52: 675-680.

  • Berliner JA, Heinecke JW. The role of oxidized low density lipoproteins in atherogenesis. Free Radic Biol Med 1996; 20: 707-727.

  • Castelli WP, Garrison RJ, Wilson PWF, Abbott RD, Kalousaian S, Kannel WB. Incidence of coronary heart disease and lipoprotein cholesterol levels. J Am Med Assoc 256: 2835-2836, 1986.

  • Craig WY, Palomaki GE, Haddow JE. Cigarette smoking and serum lipid and lipoprotein concentrations:an analysis of published data. Br Med J. 298: 784-788, 1989.

  • Criqui MH, Wallace RB, Heiss G, Mishkel M, Schnfeld G, Jones GTL. Cigarette smoking and plasma high-density lipoprotein cholesterol. The Lipid Research Clinics Program Prevalence Study. Circulation 62 (suppl 4): 70-76, 1980.

  • Demacker PNM, Vos-Janssen HE, Hijmans AGM, Van't Laar A, Jansen AP. Measurement of high-density lipoprotein cholesterol in serum:Comparison of six isolation methods combined with enzymic cholesterol analysis. Clin Chem 26 (13): 1780-1786, 1980.

  • Dullaart RP, Hoogenberg K, Dikkeschei BD, Van Tol A. Higher plasma lipid transfer protein activities and unfavorable lipoprotein changes in cigarettesmoking men. Arterioscler Thromb 14 (10): 1581-1585, 1994.

  • Goldbourt V, Holtzman E, Neufeld HN: Total and high density lipoprotein cholesterol in the serum and risk of mortality:evidence of a threshold effect. Br Med J 290: 1239-1243, 1985.

  • Garrison RJ, Kannel WB, Feinleib M, Castelli WP, McNamara PM, Padgett SJ. Cigarette smoking and HDL cholesterol: the Framingham offspring study. Atherosclerosis. (1978 May); 30(1): 17-250).

  • Ghezzi S, Risé P, Ceruti S, Galli C. Effects of cigarette smoke on cell viability, linoleic acid metabolism and cholesterol synthesis, in THP-1 cells. Lipids. 2007 Jul; 42 (7): 629-36.

  • Gleuck CJ, Heiss G, Morrison JA, Khoury P, Moore M. Alcohol in take, cigarette smoking and plasma lipids and lipoproteins in 12-19 year old children. The collaborative lipid research clinic prevalence.

  • Heitzer T, Just H, Munzel T. Antioxidant vitamin C improves endothelial dysfunction in chronic smokers. Circulation 1996; 94: 6-9.

  • Haffner SM, Applebaum-Bowden D, Wahl PW Effects of smoking, alcohol, and adiposity. Ar-teriosclerosis 5:169-177, 1985.

  • Kannel WB:Update on the role of cigarette smoking in coronary artery disease.Am . Heart J101 (3): 319-328, 1981.

  • Khurana M, Sharma D, Khandelwal PD. Lipid profile in smokers and tobacco chewers - acomparative study. J Assoc Physicians India 2000; 48: 895-897.

  • Latha MS, Vijayammal PL, Kurup PA Effect of nicotine administration on lipid metabolism in rats. Indian J Med Res 98: 44-49, 1993.

  • Lopes Paula A, Santos Maria C, Vicente Luis, Viegas-Crespo Ana. Effect of cigarette smoking on serum α-tocopherol and the lipid profile in a Portuguese population. M.; 1991 Jun 15; 97(3): 86-8.

  • Lakier JB. Smoking and cardiovascular disease.Am J Med 1992; 93: 8S-12S.

  • Hellerstein M K, N L Benowitz, R A Neese, J M Schwartz, R Hoh, P Jacob, J Hsieh, and D Faix. Effects of cigarette smoking and its cessation on lipid metabolism and energy expenditure in heavy smokers. Department of Medicine, San Francisco General Hospital, University of California 94110.

  • McCall MR, van den Berg JJ, Kuypers FA, Tribble DL, Krauss RM, Knoff LJ. Modifi-cation of LCAT activity and HDL structure. New links between cigarette smoke and coronary heart disease risk. Arterioscler Thromb 14 (2): 248-253, 1994.

  • McGill HC. Potential mechanisms for the aug-mentation of atherosclerosis and atherosclerotic disease by cigarette smoking. Prev Med 8: 390-403, 1979.

  • Dirican M, Sarandol E, Ulukaya E, Tokullugil HA. Effects of smoking on serum lipid and lipoprotein concen trations and lecithin:cholesterol acyltransferase activity. (May 11, 1999).

  • Miller GJ, Miller NE Plasma high density lipoprotein concentration and development of ischaemic heart disease. Lancet 1: 16-19, 1975.

  • Adedeji O.A. and M.H. Etukudo. Lipid Profile of Cigarette Smokers in Calabar Municipality. Department of Chemical Pathology, College of Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria, 2006.

  • Scheffler E, Wiest E, Woehrle J, Otto I, Schulz I, Huber L Smoking influences the atherogenic potential of low-density lipoprotein. Clin Invest 70: 263-268, 1992.

  • Siekmeier R, Marz W, Kronenberger H, Seiffert UB, Grob W. Effects of cigarette smoking on plasma lipids, apolipoproteins and lipoprotein (a) in healthy subjects. Clin Chem 40 (7): 1350-1351, 1994.

  • Siekmeier R, Wulfroth P, Wieland H, Groβ W, Marz W Low-density susceptibility to in vitro oxidation in healthy smokers and non-smokers. Clin Chem 42 (4): 524-530, 1996.

  • Slone D, Shapiro S, Rosenberg L et al. Relationof cigarette smoking to myocardial infraction inyoung women. N Engl J Med 1978; 298: 1273-1276.

  • Stubbe I, Eskilsson J, Nilsson-Ehle P. Highdensitylipoprotein concentrations increase after stopping smoking. Br Med J. 1982; 284: 1511-1153.

  • Shai I, Rimm EB, Hankinson SE, et al.Multivariate assessment of lipid parameters as predictors of coronary heart disease amongpostmenopausal women. Potential implications forclinical guidelines. Circulation 2004; 110: 2824-2830.

  • Stary HC, Chandler BA, Glagov S et al. Adefinition of initial, fatty steak, and intermediatelesions of atherosclerosis: a report from the Committee on Vascular Lesions of the Council onAtheriosclerosis, American Heart Association. Atheroscler Thromb 1994; 14: 840 -856.

  • Sirisali K. Kanlvan T, Poungrarin, Prabhant C.Serum lipid, lipoprotein cholesterol and apolipoproteins A-1 and B of smoking and nonsmokingmales. J Med Assoc Thai, 1992; 75: 709-713.

  • Topping DL Effects of tobacco smoke and its constituents on lipid and carbohydrate metabo- lism., eds. Bio-chemistry of cellular regulation. Boca Raton, Florida, CRC Press, 1980, Vol2, pp. 165-183.

  • Tai ES, Tan CE. Genes, diet and serum lipid concentrations: Lessons from ethically diverse populations and their relevance to coronary heart disease in Asia. Curr Opin Lipidol 2004; 15: 5-12.

  • Venkatesan.A., A. Hemalatha, Zachariah bobby,,N. Selvaraj and V. Sathiyapriya. Effect of smoking on lipid profile and lipid peroxidation in normal subjects Indian J Physiol Pharmacol 2006; 50 (3): 273-278.

  • Craig W. Y., G. E. Palomaki, and J. E. Haddow Cigarette smoking and serum lipid and lipoprotein concentrations: an analysis of published data. Foundation for Blood Research, Scarborough, ME 04074. . 1989 March 25; 298 (6676): 784-788.

  • Wendy Y. Craig PhD, Glenn E. Palomaki BS, A. Myron Johnson MD, and James E. Haddow MD .Cigarette Smoking-Associated Changes in Blood Lipid and Lipoprotein Levels in the 8-to 19-Year-Old Age Group.

  • Witztum JL, Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest 1991; 88: 1785-1791.

  • Whig J, Singh CB, Soni GL, Bansal AK. Serum lipids and lipoprotein profiles of cigarette smokers and passive smokers. Indian J Med Res 1992; 96: 282-287.


Abstract Views: 659

PDF Views: 0




  • A Comparative Study on of Lipid Profile of Smokers & Non-Smokers

Abstract Views: 659  |  PDF Views: 0

Authors

J Caroline Rose
Department of Biochemistry,AMC College, Bangalore, India
H. Vijayarani
Department of Zoology,Meenakshi College, Madurai
Helan Niruba Rani
Department of Biochemistry, KGF Dental College, Bangalore, India

Abstract


A comparative study was made between smokers and non smokers of similar age in Hosur. The aim of the present study was to assess the association between cigarette smoke and the alteration in plasma concentration of lipid profile and to assess the risk factors for cardiovascular disease between smokers and nonsmokers as increase in lipids level may lead to cardiovascular disease. Fifty smokers and fifty non-smokers were enrolled for the study. Smokers had significantly higher of total cholesterol, triglyceride, very-low-density lipoprotein (VLDL) and low-density lipoprotein (LDL) and significantly lower serum levels of high-density lipoprotein (HDL) in their serum. All the smoking-associated changes significantly increased in adult smokers. Prevalence of hypertension, hypercholesterolaemia, Hypertriglyceridaemia, hyperlipoproteinaemia was significantly greater in smokers as compared to nonsmokers.

Keywords


Smoking, Lipids, Lipoproteins, Risk Factors, Cardiovascular, Cholesterol, Hypertension, Hypercholesterolemia, Hypertriglyceridaemia

References