Diospyros mespiliformis, is an evergreen tree found mostly in the savannas of Africa. The leaves have wide applications in traditional medicine which includes whooping cough, wound dressing, pneumonia, syphilis, arthritis and skin infections. The preliminary phytochemical screening showed the presence of cardiac glycosides, terpenoids, alkaloids, saponins, tannins, anthraquinones and flavonoids. The in vitro antibacterial study of crude methanol leaf extract (CME) was analysed using disc diffusion method (DDM), with twogram positive (Staphylococcus aureus and Streptococcus pneumonia) and two-gram negative (Escherichia coli and Pseudomonas aeruginosa) bacteria. The standard antibiotic disc used was gentamicin (5µg/disc). The CME showed highest activity against Streptococcus pneumonia (12.5±1.12mm) at 150mg/ml and the lowest activity was seen against Staphylococcus aureus (11.5±1.11mm) at 200mg/ml as compared to 31.0±0.82mm and 41.0±0.82mm of the control (standard drug) respectively. Pseudomonas aeruginosa showed resistance against the CME at all concentrations including the standard drug.
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