Scientia Pharmaceutica

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Investigation of Certain Varieties of Carbopol in Ketorolac Tromethamine Hydrophilic Matrix Tablet Formulations and Evaluation of The Kinetics of its in Vitro Release


Affiliations
1 Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 26470 Eskisehir, Turkey
2 Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100 Ankara, Turkey
     

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Matrix tablets of ketorolac trometharnine (KT) were prepared by direct compression technique and Carbopol 934, 940 and 1342 have been used as polymers in different concentrations (5-15 %). For the quality control of tablets; physical tests as crushing strength, diameter-height ratio and fkiability, KT amount assay and in vitro dissolution techniques were performed and dissolution profiles were plotted and evaluated kinetically. The in vitro release kinetics of ten different formulations of KT matrix tablet were studied at pH 1.2 and pH 7.0 using the USP dissolution technique and apparatus with basket assembly. Dissolution results were evaluated kinetically and statistically. According to our results, different types and concentrations of carbopol to tablet formulations may effect in controlled drug release.

Keywords

Hydrophilic Matrix Tablet, Carbopol, Ketorolac Tromethamine, In Vitro Release Kinetics, Sustained Release
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  • Investigation of Certain Varieties of Carbopol in Ketorolac Tromethamine Hydrophilic Matrix Tablet Formulations and Evaluation of The Kinetics of its in Vitro Release

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Authors

Lutfi Genc
Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 26470 Eskisehir, Turkey
Nahed Hegazy
Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 26470 Eskisehir, Turkey
Betul Arica
Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100 Ankara, Turkey

Abstract


Matrix tablets of ketorolac trometharnine (KT) were prepared by direct compression technique and Carbopol 934, 940 and 1342 have been used as polymers in different concentrations (5-15 %). For the quality control of tablets; physical tests as crushing strength, diameter-height ratio and fkiability, KT amount assay and in vitro dissolution techniques were performed and dissolution profiles were plotted and evaluated kinetically. The in vitro release kinetics of ten different formulations of KT matrix tablet were studied at pH 1.2 and pH 7.0 using the USP dissolution technique and apparatus with basket assembly. Dissolution results were evaluated kinetically and statistically. According to our results, different types and concentrations of carbopol to tablet formulations may effect in controlled drug release.

Keywords


Hydrophilic Matrix Tablet, Carbopol, Ketorolac Tromethamine, In Vitro Release Kinetics, Sustained Release

References