Scientia Pharmaceutica

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Synthesis of New Piperidine and Cyclohexylamino-Spiro Derivatives as Potential Anticalcium Agents


Affiliations
1 Laboratori de Quimica Farmaceutica, Facultat de Farmacia, Universitat de Barcelona, Av. Diagonal 643, 08028 Barcelona, Spain
2 lnstitut de Chimie Organique et Analytique associe au CNRS, Universite d'Orleans, BP 6957, 45067 Orleans Cedex 2, France
3 UCB Pharma, Pharmaceutical Sector, Chemin du Foriest, B-1420 Braine-L'Alleud, Belgium
4 Laboratoire RL-CERM, ZI La Varenne, rue H. Goudier, 63203 Riom, Cedex, France
     

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The synthesis of new 1,3-benzodioxolo and 1,4-benzodioxan spiro derivatives containing a piperidine (4-6) or cyclohexylamino (7-8) group have been described. These compounds exhibit in vitro a moderate anticalcium activity.

Keywords

Spiro Compounds, 1,3-Benzodioxole, 1,3-Benzodioxan, Anticalcium Activity
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  • a. Janssen, P. A. US3, 238, 216, 1966. b. Galizzi, J. P.; Fosset, M.; Barhanin, J.; Romey, G.; Laduron, P.; Lazdunski, M.; Proc. Natl. Acad. Sci. 1986, 83, 7513.

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  • Synthesis of New Piperidine and Cyclohexylamino-Spiro Derivatives as Potential Anticalcium Agents

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Authors

Isabel Sanchez
Laboratori de Quimica Farmaceutica, Facultat de Farmacia, Universitat de Barcelona, Av. Diagonal 643, 08028 Barcelona, Spain
Maria Dolors Pujol
Laboratori de Quimica Farmaceutica, Facultat de Farmacia, Universitat de Barcelona, Av. Diagonal 643, 08028 Barcelona, Spain
Gerald Guillaumet
lnstitut de Chimie Organique et Analytique associe au CNRS, Universite d'Orleans, BP 6957, 45067 Orleans Cedex 2, France
Roy Massingham
UCB Pharma, Pharmaceutical Sector, Chemin du Foriest, B-1420 Braine-L'Alleud, Belgium
Andre Monteil
Laboratoire RL-CERM, ZI La Varenne, rue H. Goudier, 63203 Riom, Cedex, France

Abstract


The synthesis of new 1,3-benzodioxolo and 1,4-benzodioxan spiro derivatives containing a piperidine (4-6) or cyclohexylamino (7-8) group have been described. These compounds exhibit in vitro a moderate anticalcium activity.

Keywords


Spiro Compounds, 1,3-Benzodioxole, 1,3-Benzodioxan, Anticalcium Activity

References