Scientia Pharmaceutica

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The Beneficial Interaction Between Enalapril and Danazol in Normal Rat


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1 Department of Pharmacology, College of Pharmacy, King Saud University, P.O Box 2457, Riyadh 11451, Saudi Arabia
     

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Danazol, a weekly androgenic, heterocyclic compound with anabolic properties, is used primarily in the treatment of endometriosis and other gynecological complaints. Effects of co-administration of enalapril, an angiotensin converting enzyme inhibitor (ACE inhibitor) with danazol on some biochemical parameters in rats were studied. Treatment of rats with danazol (200mg/kg i.p) for 15 days induced a significant elevation of serum aspartate transaminase activity (AST, EC: 2.6.1.1), triglycerides (TG) and induced a significant decrease in serum cholesterol. However, enalapril treatment (20mg/kg i.p) for 15 days caused a significant elevation of serum alanine transaminase activity (ALT, EC: 2.6.1.2). Co-administration of danazol and enalapril significantly lowered the elevated levels of serum transaminases enzyme activities and serum TG. It could be concluded that long term treatment with enalapril might be beneficial in patients danazol in clinical situations through protection against undesirable side effects.
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  • The Beneficial Interaction Between Enalapril and Danazol in Normal Rat

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Authors

M. Mansour
Department of Pharmacology, College of Pharmacy, King Saud University, P.O Box 2457, Riyadh 11451, Saudi Arabia
T. El-Hadiyah
Department of Pharmacology, College of Pharmacy, King Saud University, P.O Box 2457, Riyadh 11451, Saudi Arabia
O. Ginawi
Department of Pharmacology, College of Pharmacy, King Saud University, P.O Box 2457, Riyadh 11451, Saudi Arabia
A. Mostafa
Department of Pharmacology, College of Pharmacy, King Saud University, P.O Box 2457, Riyadh 11451, Saudi Arabia
A. Al-Majed
Department of Pharmacology, College of Pharmacy, King Saud University, P.O Box 2457, Riyadh 11451, Saudi Arabia
O. Al-Shabanah
Department of Pharmacology, College of Pharmacy, King Saud University, P.O Box 2457, Riyadh 11451, Saudi Arabia

Abstract


Danazol, a weekly androgenic, heterocyclic compound with anabolic properties, is used primarily in the treatment of endometriosis and other gynecological complaints. Effects of co-administration of enalapril, an angiotensin converting enzyme inhibitor (ACE inhibitor) with danazol on some biochemical parameters in rats were studied. Treatment of rats with danazol (200mg/kg i.p) for 15 days induced a significant elevation of serum aspartate transaminase activity (AST, EC: 2.6.1.1), triglycerides (TG) and induced a significant decrease in serum cholesterol. However, enalapril treatment (20mg/kg i.p) for 15 days caused a significant elevation of serum alanine transaminase activity (ALT, EC: 2.6.1.2). Co-administration of danazol and enalapril significantly lowered the elevated levels of serum transaminases enzyme activities and serum TG. It could be concluded that long term treatment with enalapril might be beneficial in patients danazol in clinical situations through protection against undesirable side effects.

References