Scientia Pharmaceutica

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Triflate-Mediated Synthesis of 3-(4-Methoxyquinazolin-2-yl)-Quinazolin-2,4-(1H,3H)-Dione and Its Antimicrobial Activity


Affiliations
1 Departments of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
2 Pharmaceutical Microbiology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
     

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The synthesis of a novel quinazolinone was accomplished by the reaction of quinazolin-2,4-(1H,3H)-dione with trifluoromethanesulfonic anhydride in triethylamine. The antimicrobial activity was determined against eight microorganisms. The organisms were all susceptible to 3-(4-methoxyquinazolin-2-yl)-quinazolin-2,4-(1H,3H)-dione 3 at the concentrations used. The gram positive organisms showed more susceptibility than the gram negative ones.

Keywords

Quinazolinoe, Triflate, Antimicrobial Activity
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  • Triflate-Mediated Synthesis of 3-(4-Methoxyquinazolin-2-yl)-Quinazolin-2,4-(1H,3H)-Dione and Its Antimicrobial Activity

Abstract Views: 172  |  PDF Views: 0

Authors

C. O. Usifoh
Departments of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
G. C. Ukoh
Pharmaceutical Microbiology, Faculty of Pharmacy, University of Benin, Benin City, Nigeria

Abstract


The synthesis of a novel quinazolinone was accomplished by the reaction of quinazolin-2,4-(1H,3H)-dione with trifluoromethanesulfonic anhydride in triethylamine. The antimicrobial activity was determined against eight microorganisms. The organisms were all susceptible to 3-(4-methoxyquinazolin-2-yl)-quinazolin-2,4-(1H,3H)-dione 3 at the concentrations used. The gram positive organisms showed more susceptibility than the gram negative ones.

Keywords


Quinazolinoe, Triflate, Antimicrobial Activity

References