SMU Medical Journal

Zeinab Heidari Pebdani ¹

Affiliations
1 Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, IR, IR

Abstract

Drug Ionic liquids have been widely studied in Medicine for the replacement of VOCs in organic chemistry for the synthesis of biologically active compounds including Active Pharmaceutical Ingredients (APIs). ILs and antimicrobial or antibacterial activity, antibiofilm activity, ILs and antitumor activity, biotechnology and toxicity of ionic liquids, and biomedical applications (use of ILs to boosting MRI), all these are important for Medical applications. To overcome problems pharmaceutical process, ionic liquids (ILs) have been increasingly exploited as solvents and or (co) solvents and or reagents in a wide range of pharmaceutical applications due to their tailormade chemical, physical and biological properties. The Bronsted Acidic Ionic Liquids (BAILs) [Bu₃NH]H₂PO₄, [Bu₃NH]HSO₄, [Bu₃NH]NO₃, [Bu₃NH]Cl, were synthesized and characterized instruments tending: TLC, FT-IR, ¹H-NMR and elemental analysis. Experimental densities(ρ)dynamic viscosities (η), surface tension (σ), electrical conductivity (κ), refractive indices (n_D) and thermal conductivity (λ), that were investigated as a function of temperature under (293.15 to 363.15) K conditions, for binary systems with water ionic liquids at atmospheric pressure. A standard and effective method to evaluate the acidity of Bronsted acids was the Hammett method (H_o) which might use them for BAILs, pH and pKa. Conjointly, densities, dynamic viscosity, surface tension, ionic conductivity, refractive indices and thermal conductivity deviations, and dynamic viscosity deviations in for the binary systems with water were fitted to a Vogel-Fulcher-Tammann (VFT) equation. The current synthesized ionic liquids show a weak temperature dependency on the physical properties.

Keywords

Ionic Liquids, Medical Chemistry, Pharmaceutical Salts, Physical Properties, Temperature Dependence, Water, Molecular Interactions.

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Zeinab Heidari Pebdani ¹

Affiliations
1 Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, IR, IR

Abstract

Drug Ionic Liquids (ILs) have been broadly studied in Medicine and Industrials for the replacement of VOCs in organic chemistry for the synthesis of biologically active compounds including Active Pharmaceutical Ingredients (APIs). ILs and antimicrobial or antibacterial activity, antibiofilm activity, ILs and antitumor activity, biotechnology and toxicity of ionic liquids, and biomedical applications (use of ILs to boosting MRI), all these are important for Medical applications. We investigated functions of temperature, densities (ρ), dynamic viscosities (η), surface tension (σ), ionic conductivity (κ), refractive indices (n_D), and thermal conductivity (λ) for the binary systems of the DMSO with ionic liquids as pharmaceutical salts over the whole composition range at temperature from 298.15 to 363.15K under atmospheric pressure. The ILs investigated in this study comprised [Bu₃NBn]Cl-2(MCl_m), (MCl_m = AlCl₃), CuCl₂, FeCl₃, SnCl₄, ZnCl₂) which we synthesized in our laboratory. By using TLC, CHNS, FTIR and Mass Spectroscopy, the temperature influence on the thermophysical properties on thenew series of room-temperature ionic liquids (RTILs) prepared and characterized. Thermogravimetric analysis (TGA) confirmed that ILs are stable at the temperature range of 400-800°C. We used the Hammett method (H_o) which is a common and effective way to evaluate the acidity of Lewis acids. Also densities, dynamic viscosities, surface tensions, ionic conductivities, refractive indices and thermal conductivity deviations, and dynamic viscosity deviations for the binary systems with DMSO were fitted to a Vogel-Fulcher-Tammann (VFT) equation.

Keywords

Ionic Liquids, Medical Chemistry, Pharmaceutical Salts, Physical And Thermophysical Properties, DMSO, Molecular Interactions.

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