Studies on Thermophysical Properties of Lewis Acidic Ionic Liquids for Medical Use

Drug Ionic Liquids (ILs) have been broadly studied in Medicine and Industrials for the replacement of VOCs in organic chemistry for the synthesis of biologically active compounds including Active Pharmaceutical Ingredients (APIs). ILs and antimicrobial or antibacterial activity, antibiofilm activity, ILs and antitumor activity, biotechnology and toxicity of ionic liquids, and biomedical applications (use of ILs to boosting MRI), all these are important for Medical applications. We investigated functions of temperature, densities (ρ), dynamic viscosities (η), surface tension (σ), ionic conductivity (κ), refractive indices (n_D), and thermal conductivity (λ) for the binary systems of the DMSO with ionic liquids as pharmaceutical salts over the whole composition range at temperature from 298.15 to 363.15K under atmospheric pressure. The ILs investigated in this study comprised [Bu₃NBn]Cl-2(MCl_m), (MCl_m = AlCl₃), CuCl₂, FeCl₃, SnCl₄, ZnCl₂) which we synthesized in our laboratory. By using TLC, CHNS, FTIR and Mass Spectroscopy, the temperature influence on the thermophysical properties on thenew series of room-temperature ionic liquids (RTILs) prepared and characterized. Thermogravimetric analysis (TGA) confirmed that ILs are stable at the temperature range of 400-800°C. We used the Hammett method (H_o) which is a common and effective way to evaluate the acidity of Lewis acids. Also densities, dynamic viscosities, surface tensions, ionic conductivities, refractive indices and thermal conductivity deviations, and dynamic viscosity deviations for the binary systems with DMSO were fitted to a Vogel-Fulcher-Tammann (VFT) equation.