SMU Medical Journal

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Diabetes mellitus, a metabolic syndrome characterized by chronic hyperglycemia causes serious morbidity and mortality worldwide. Several allopathic drugs are available to treat diabetes but management without any side effects is still a challenge to the medical system; hence phytocompounds are getting more importance. Number of plant based compounds has been identified as potential antidiabetics. Caffeic acid, isolated from edible plant species has wide range of pharmacological effects. Recently, antidiabetic activities of caffeic acid are being explored. This review of the current literature discuss in detail about the antidiabetic actions of caffeic acid, including; antidegenerative effect on islets, up-regulation adipocytes GLUT-4, inhibition of alpha-amylase and alpha-glucosidase activity, increase mRNA expression of glucokokinase, decrease in glucose-6-phosphatase and phosphoenolpyruvate carboxykinase activities and regulation of beta-cell function.

Keywords

Antidiabetic Activities, Caffeic Acid, Diabetes Mellitus.
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