Research Journal of Science and Technology

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Recent Synthesis of Marine Natural Products with Anticancer Activity:An Overview


Affiliations
1 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, A/PLoni Bk., Taluka -Rahata, Dist-Ahmednagar 413736, India
2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), India
3 Department of Pharmaceutics, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), India
     

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Many natural products from marine sources are endowed with promising anti cancer activity, thus representing invaluable leads in the plans for drug discovery. In this context, organic synthesis plays a decisive role in confirming (or revising) the chemical structures of the natural compounds allowing also access to suitable amounts of the target (and its analogs) for structure activity relationship (SAR) investigations. In this overview, we focus on the total and partial synthesis of anti cancer marine metabolites and their related compounds discussing the retro synthetic analysis of the strategies adopted.

Keywords

Marine, Anti Cancer Activity, Synthesis of Dictyostatin.
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  • Recent Synthesis of Marine Natural Products with Anticancer Activity:An Overview

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Authors

Nachiket S. Dighe
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, A/PLoni Bk., Taluka -Rahata, Dist-Ahmednagar 413736, India
Shashikant R. Pattan
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), India
Deepak S. Musmade
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), India
Abhijeet N. Merekar
Department of Pharmaceutics, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), India
Manisha S. Kedar
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), India
Deepak K. Thakur
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), India
Pratik V. Patel
Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, 413736 (MS), India

Abstract


Many natural products from marine sources are endowed with promising anti cancer activity, thus representing invaluable leads in the plans for drug discovery. In this context, organic synthesis plays a decisive role in confirming (or revising) the chemical structures of the natural compounds allowing also access to suitable amounts of the target (and its analogs) for structure activity relationship (SAR) investigations. In this overview, we focus on the total and partial synthesis of anti cancer marine metabolites and their related compounds discussing the retro synthetic analysis of the strategies adopted.

Keywords


Marine, Anti Cancer Activity, Synthesis of Dictyostatin.