Formulation and Evaluation of Ibuprofen Solid-Dispersions Prepared by Solvent Evaporation Technique

Solid dispersion is the science of dispersing one (or) more active ingredients in an inert carriers (or) matrix at solid state prepared by melting solvent method (or) solvent evaporation method. Sparingly water soluble drugs often show an erratic dissolution profile in gastrointestinal fluids which consequently results variable oral bio-availability. To improve the dissolution and bioavailability of these drugs, various techniques such as solvent evaporation method, melting method, super critical fluid process, spray drying, lyophilisation, melt agglomeration, extrusion kneading method. The various inert carriers such as acids, polymeric materials, insoluble (or) enteric polymers, surfactants etc. PEG, PVP, lactose, Mannitol, Cyclodextrins and HPMC were used to increased solubility. Solid dispersions were prepared by solvent evaporation method. Solid dispersions of ibuprofen were prepared to increase its aqueous solubility using carriers such as mannitol, urea, and sorbitol. Ibuprofen solid dispersions were prepared in 1:1, 1:2 and 1:3 ratios of the drug to carriers (w/w). The prepared solid dispersion were evaluated for physical parameters like Angle of repose, Bulk density, Carr’s index, Hausner ratio and Invitro drug release studies. Invitro drug release profile of solid dispersions were comparatively evaluated and also studied against pure Ibuprofen. Higher dissolution rate were exhibited by solid dispersions containing 1:3 ratio of Ibuprofen with urea, the rate of drug release was depended on the type, ratio of drug to carrier and method of dispersions.