Research Journal of Pharmacology and Pharmacodynamics

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Study of Antidiabetic and Free Radical Scavenging Activity of the Methanolic and N-Hexane Extract of Asystasia gangetica Leaf in Alloxan Induced Diabetic Rats


Affiliations
1 Department of Pharmacology, Siddhartha Institute of Pharmaceutical Sciences, Narsaraopet, Guntur (DT), Andhra Pradesh, India
2 Department of Pharmacology, S.R.M. College of Pharmacy, Kattakulathur, Tamilnadu, India
3 Siddhartha Institute of Pharmaceutical Sciences, Narsaraopet, Guntur (Dt), Andhra Pradesh, India
4 Department of Biotechnology, Narsaraopet, Guntur(DT), Andhra Pradesh, India
     

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The present work is carried out to study the effect of Asystasia gangetica T. Adams (Acanthaceae) on blood glucose levels and antioxidant enzymes levels in Alloxan induced diabetic rats. Alloxan (120 mg/kg, i.p) induced diabetic rats were treated with Asystasia gangetica leaf methanolic and n-hexane extract for 21 days. Glucose level was measured in blood serum and antioxidant enzymes levels viz. superoxide dismutase (SOD), catalase (CAT) and lipid peroxidase (LPO) were measured in liver homogenate solution, methanolic and n-hexane extract of leaf of Asystasia gangetica T. Adams significantly (P<0.01) lowered the Alloxan induced hyperglycemia. It also produced a significant (P<0.01) decrease in peroxidation product viz. MDA in liver homogenate solution. The activity of antioxidant enzymes such as SOD, CAT were found to be increased in the liver homogenate solution of diabetic animals treated with the Asystasia gangetica T. Adams leaf extract. This confirms the antihyperglycemic and antioxidant activity of Asystasia gangetica T. Adams in Alloxan induced diabetic rats.

Keywords

Asystasia gangetica T. Adams, Alloxan, Superoxide Dismutase (SOD), Catalase (CAT) and Lipid Peroxidase (LPO).
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  • Study of Antidiabetic and Free Radical Scavenging Activity of the Methanolic and N-Hexane Extract of Asystasia gangetica Leaf in Alloxan Induced Diabetic Rats

Abstract Views: 281  |  PDF Views: 0

Authors

G. Lakshmana
Department of Pharmacology, Siddhartha Institute of Pharmaceutical Sciences, Narsaraopet, Guntur (DT), Andhra Pradesh, India
V. Chitra
Department of Pharmacology, S.R.M. College of Pharmacy, Kattakulathur, Tamilnadu, India
D. Rajesh Kumar
Department of Pharmacology, Siddhartha Institute of Pharmaceutical Sciences, Narsaraopet, Guntur (DT), Andhra Pradesh, India
P. Dayakar Reddy
Department of Pharmacology, Siddhartha Institute of Pharmaceutical Sciences, Narsaraopet, Guntur (DT), Andhra Pradesh, India
R. Srinivasan
Siddhartha Institute of Pharmaceutical Sciences, Narsaraopet, Guntur (Dt), Andhra Pradesh, India
G. Rajeswari Devi
Department of Biotechnology, Narsaraopet, Guntur(DT), Andhra Pradesh, India

Abstract


The present work is carried out to study the effect of Asystasia gangetica T. Adams (Acanthaceae) on blood glucose levels and antioxidant enzymes levels in Alloxan induced diabetic rats. Alloxan (120 mg/kg, i.p) induced diabetic rats were treated with Asystasia gangetica leaf methanolic and n-hexane extract for 21 days. Glucose level was measured in blood serum and antioxidant enzymes levels viz. superoxide dismutase (SOD), catalase (CAT) and lipid peroxidase (LPO) were measured in liver homogenate solution, methanolic and n-hexane extract of leaf of Asystasia gangetica T. Adams significantly (P<0.01) lowered the Alloxan induced hyperglycemia. It also produced a significant (P<0.01) decrease in peroxidation product viz. MDA in liver homogenate solution. The activity of antioxidant enzymes such as SOD, CAT were found to be increased in the liver homogenate solution of diabetic animals treated with the Asystasia gangetica T. Adams leaf extract. This confirms the antihyperglycemic and antioxidant activity of Asystasia gangetica T. Adams in Alloxan induced diabetic rats.

Keywords


Asystasia gangetica T. Adams, Alloxan, Superoxide Dismutase (SOD), Catalase (CAT) and Lipid Peroxidase (LPO).

References