Research Journal of Pharmacology and Pharmacodynamics

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A Review on Alzheimer's Disease


Affiliations
1 Department of Pharmacology, Siddhartha Institute of Pharmaceutical Sciences, Narsaraopet, Guntur (DT), Andhra Pradesh, India
2 Siddhartha Institute of Pharmaceutical Sciences, Narsaraopet, Guntur (Dt.), Andhra Pradesh India, India
3 SIMS College of Pharmacy, Guntur, Andhra Pradesh, India
     

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Alzheimer's disease is a neurological disorder in which the death of brain cells causes memory loss and cognitive decline. More than 25 million people in the world today are affected by dementia, most suffering from Alzheimer's disease. There are three stages of the condition mild, moderate and severe. The symptoms are also varies from stage to stage. Some of the causes of this disease includes age, family history, Down's syndrome and vascular disease. Mainly it occurs due to presence of extracellular amyloid plaques and intracellular neurofibrillary tangles. Diagnosis can be done by using CT scan, MRI scan and Cognitive tests. Cholinesterase inhibitors and partial glutamate antagonists are used for the treatment. It can be prevented by performing some of activities like reading, writing and learning foreign languages.

Keywords

Alzheimer's Disease, Dementia, Down's Syndrome, Amyloid Plaques and Cholinesterase Inhibitors.
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Abstract Views: 355

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  • A Review on Alzheimer's Disease

Abstract Views: 355  |  PDF Views: 3

Authors

D. Rajesh Kumar
Department of Pharmacology, Siddhartha Institute of Pharmaceutical Sciences, Narsaraopet, Guntur (DT), Andhra Pradesh, India
M. Siva Shankar
Siddhartha Institute of Pharmaceutical Sciences, Narsaraopet, Guntur (Dt.), Andhra Pradesh India, India
P. Prathap Reddy
Siddhartha Institute of Pharmaceutical Sciences, Narsaraopet, Guntur (Dt.), Andhra Pradesh India, India
B. Ram Sarath Kumar
SIMS College of Pharmacy, Guntur, Andhra Pradesh, India
N. Sumalatha
SIMS College of Pharmacy, Guntur, Andhra Pradesh, India

Abstract


Alzheimer's disease is a neurological disorder in which the death of brain cells causes memory loss and cognitive decline. More than 25 million people in the world today are affected by dementia, most suffering from Alzheimer's disease. There are three stages of the condition mild, moderate and severe. The symptoms are also varies from stage to stage. Some of the causes of this disease includes age, family history, Down's syndrome and vascular disease. Mainly it occurs due to presence of extracellular amyloid plaques and intracellular neurofibrillary tangles. Diagnosis can be done by using CT scan, MRI scan and Cognitive tests. Cholinesterase inhibitors and partial glutamate antagonists are used for the treatment. It can be prevented by performing some of activities like reading, writing and learning foreign languages.

Keywords


Alzheimer's Disease, Dementia, Down's Syndrome, Amyloid Plaques and Cholinesterase Inhibitors.

References