Research Journal of Pharmacology and Pharmacodynamics

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Anti-Obesity Activities of Hydro-Alcoholic Extract of Echinochloa crusgalli (L.) P. Beauv Grains in Albino Rats


Affiliations
1 Department of Pharmacology, Gautham College of Pharmacy, Bangalore, Karnataka, India
     

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Obesity is often defined simply as a condition of abnormal or excessive fat accumulation in adipose tissue, to the extent that health may be impaired. The present study was undertaken to evaluate anti-obesity effect of hydro-alcoholic extracts of Echinochloa crusgalli on high fat diet induced obesity in albino rats. Obesity was induced by administration of high fat diet for 4 weeks with normal diet and obtained obese rats were treated with Echinochloa crusgalli in a dose of 200, 400 and 600 mg/kg, b.w. p.o for next 4 weeks. It showed significant decrease in body weights, adipose tissue weight, SGOT and SGPT levels, blood glucose levels, LDL-C, VLDL-C, total cholesterol, triglyceride levels, atherogenic index, and also showed significant increase in HDL-C levels when compared with high fat diet control.

Keywords

Obesity, Echinochloa crusgalli, High Fat Diet, Body Weight, Adipose Tissue Weight, Lipid Profile, Atherogenic Index, Serum Blood Glucose Levels.
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  • Benjamin C. The global epidemic of obesity: an overview. Epidemiol Rev. 2007;29:1-5.

  • Ekanem AP, Wang M, Simon JE, Moreno DA. Anti-obesity properties of two african plants (Afromomum meleguetta and Spilanthes acmella) by pancreatic lipase inhibition. Phytother Res. 2007;21:1253-55.

  • WHO – obesity and overweight – world health organisation. Cited 2013 Jul 16. Available from: http://www.who.int/mediacentre/factsheets/fs311/en/.

  • Mason P. Obesity -new insights into a growing problem. Pharm J. 1997;258:800-2.

  • Obesity diagnosis and treatment algorithm. Cited 2013 Jul 16. Available from: http://www.bcmj.org/article/obesity-diagnosisand-treatment-algorithm.

  • lmaz I, Cervell M, Garcia EE, Sendra JM, Gonzalez EJ. Safety and effectiveness of the intragastric balloon for obesity. A metaanalysis. Obes Surg. 2008;18(7):841-6.

  • Hemanna K, Narayana M, Veena T, Narayana H D, Jaya Kumar K. Hyperlipidemic effect of Fenugreek (Trigonella foenum graecum) and Turmeric (Curcuma longa) in diet induced hyperlipidemia rats. Int J Drug Disc Tech. 2010;1:75-80.

  • Saikia H, Lama A. Effect of Bougainvillea spectabilis leaves on serum lipids in albino rats fed with high fat diet. Int J Pharm Sci Drug Res. 2011;3(2):141-5.

  • Triglycerides - Cornell university. Cited 2013 Aug 6. Available: https://ahdc.vet.cornell.edu/clinpath/modules/chem/triglyc.htm.

  • Franz MJ. Protein: metabolism and effect on blood glucose levels. Cited 2013 Aug 6. Available from: http://www.ncbi.nlm.nih.gov/pubmed/9416027.

  • Diabetes and Obesity - Diabetic care services. Cited 2013 Aug 9. Available from: http://www.diabeticcareservices.com/diabeteseducation/diabetes-and-obesity.

  • Venkatesh S, Dayananda RG, Madhava RB, Lakshman M. Antidiabetic activity of Helicteres isora ischolar_main. Cited 2013 Aug 9. Available from: http://www.ayurvedam.com/pdf/antidiabetic.pdf.

  • G. Boden, Jadali F, White J, Liang Y, Mozzoll M, Chen X. Effects of fat on insulin-stimulated carbohydrate metabolism in normal men. Cited 2013 Aug 12. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC295496/pdf/jcinvest00062-0242.pdf.

  • Bart S, Jean D, Johan A, Kristina S, Eran L, Jean C. Mechanism of action of fibrates on lipid and lipid metabolism. Cited 2013 Aug 12. Available from: http://circ.ahajournals.org/content/98/19/2088.full.

  • Ikonen E. Mechanisms for cellular cholesterol transport: defects and human disease, Physiol Rev. 2006;86(4):1237–61. Cited 2013 Aug 8. Available from: http://www.hindawi.com/isrn/pharmacology/2011/505247/.

  • Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerol. Cited 2013 Aug 18. Available from: http://www.sciencedirect.com/science/article/pii/0005276086902869.

  • Allen DO, Ahmed B, Naseer K. Relationships between cyclic AMP levels and lipolysis in fat cells after isoproterenol and forskolin stimulation. J Pharmacol Exp ther. 1986 Aug;238(2):659-64. Cited 2013 Aug 18. Available from: http://www.ncbi.nlm.nih.gov/pubmed/3016246.

  • Hong XZ, Li LD, Wu LM. Effects of fenofibrate and xuezhikang on high-fat diet-induced non-alcoholic fatty liver disease. Clin Exp Pharmacol physiol. 2007 Jan-Feb;34(1-2):27-35. Cited 2013 Aug 18. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17201732.

  • Seo YS, Kim JH, Jo NY, Choi KM, Baik SH, Park JJ, et al. PPAR agonists treatment is effective in a nonalcoholic fatty liver disease animal model by modulating fatty-acid metabolic enzymes. Gastroenterol Hepatol. 2008 Jan;23(1):102-9. Cited 2013 Aug 3. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18171348 J.

  • What are function of SGOT, SGPT and BILIRUBIN ? Cited 23-08-2013. Available from: http://in.answers.yahoo.com/question/index?qid=20091125075731AAZzP64.


Abstract Views: 285

PDF Views: 3




  • Anti-Obesity Activities of Hydro-Alcoholic Extract of Echinochloa crusgalli (L.) P. Beauv Grains in Albino Rats

Abstract Views: 285  |  PDF Views: 3

Authors

Maradani Pavani
Department of Pharmacology, Gautham College of Pharmacy, Bangalore, Karnataka, India
Bandenawaz Ramadurg
Department of Pharmacology, Gautham College of Pharmacy, Bangalore, Karnataka, India
C. Varshitha
Department of Pharmacology, Gautham College of Pharmacy, Bangalore, Karnataka, India

Abstract


Obesity is often defined simply as a condition of abnormal or excessive fat accumulation in adipose tissue, to the extent that health may be impaired. The present study was undertaken to evaluate anti-obesity effect of hydro-alcoholic extracts of Echinochloa crusgalli on high fat diet induced obesity in albino rats. Obesity was induced by administration of high fat diet for 4 weeks with normal diet and obtained obese rats were treated with Echinochloa crusgalli in a dose of 200, 400 and 600 mg/kg, b.w. p.o for next 4 weeks. It showed significant decrease in body weights, adipose tissue weight, SGOT and SGPT levels, blood glucose levels, LDL-C, VLDL-C, total cholesterol, triglyceride levels, atherogenic index, and also showed significant increase in HDL-C levels when compared with high fat diet control.

Keywords


Obesity, Echinochloa crusgalli, High Fat Diet, Body Weight, Adipose Tissue Weight, Lipid Profile, Atherogenic Index, Serum Blood Glucose Levels.

References