Research Journal of Pharmacology and Pharmacodynamics

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Hepatoprotective and Antioxidant Potential of Calotropis gigantea in Cyclosporine-An Induced Hepatotoxicity


Affiliations
1 Pad. Dr. D. Y. Patil Institute of Pharmaceutical sciences and research, Pimpari, Pune-411 018, India, India
2 AISSMS College of Pharmacy, Near RTO, Kennedy road, Pune-411 001, India
3 Department of Pharmacology, K.L.E.S's College of Pharmacy, Bangalore-560010, India
     

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The ethanolic fraction of Calotropis gigantea flowers (CGFE) was evaluated for its possible hepatoprotective potential in Wistar rats. The CGFE (250mg/kg and 500mg/kg, bw p.o.) showed a remarkable hepatoprotective activity against cyclosporine-A induced hepatotoxicity as judged from the level of serum markers for liver damage. Cyclosporine-A induced a significant rise in serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and lipid profile levels. The cotreatment of animals with CGFE (250mg/kg and 500mg/kg, p.o.) significantly decreased the elevated serum marker enzyme and lipid profile levels near to normal. The activity of the CGFE was comparable to the standard drug, silymarin (100mg/kg, p.o.). Further histopathological studies support the above finding.

Keywords

Antioxidant, Calotropis gigantea, Cyclosporine-A, Hepatotoxicity.
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  • Hepatoprotective and Antioxidant Potential of Calotropis gigantea in Cyclosporine-An Induced Hepatotoxicity

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Authors

Ajay Kshirsagar
Pad. Dr. D. Y. Patil Institute of Pharmaceutical sciences and research, Pimpari, Pune-411 018, India, India
Deepa Ingawale
AISSMS College of Pharmacy, Near RTO, Kennedy road, Pune-411 001, India
Purnima Ashok
Department of Pharmacology, K.L.E.S's College of Pharmacy, Bangalore-560010, India
Vrushali Thorve
AISSMS College of Pharmacy, Near RTO, Kennedy road, Pune-411 001, India
Tanmay Dodal
AISSMS College of Pharmacy, Near RTO, Kennedy road, Pune-411 001, India
Anurag Dodal
AISSMS College of Pharmacy, Near RTO, Kennedy road, Pune-411 001, India
Mahesh Kahane
AISSMS College of Pharmacy, Near RTO, Kennedy road, Pune-411 001, India
Bharat Zope
AISSMS College of Pharmacy, Near RTO, Kennedy road, Pune-411 001, India

Abstract


The ethanolic fraction of Calotropis gigantea flowers (CGFE) was evaluated for its possible hepatoprotective potential in Wistar rats. The CGFE (250mg/kg and 500mg/kg, bw p.o.) showed a remarkable hepatoprotective activity against cyclosporine-A induced hepatotoxicity as judged from the level of serum markers for liver damage. Cyclosporine-A induced a significant rise in serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and lipid profile levels. The cotreatment of animals with CGFE (250mg/kg and 500mg/kg, p.o.) significantly decreased the elevated serum marker enzyme and lipid profile levels near to normal. The activity of the CGFE was comparable to the standard drug, silymarin (100mg/kg, p.o.). Further histopathological studies support the above finding.

Keywords


Antioxidant, Calotropis gigantea, Cyclosporine-A, Hepatotoxicity.

References