Research Journal of Pharmacology and Pharmacodynamics

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Biochemical Evaluation of Hypoglycemic, Hypolipidemic and Antioxidant Properties of Lippia nodiflora Leaves Studied in Alloxan-Induced Experimental Diabetes in Rats


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1 Department of Biochemistry, University of Madras, Guindy Campus, Chennai - 600 025, Tamil Nadu, India
     

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Lippia nodiflora, a perennial herb, has been reported to possess a number of pharmacological activities and used for various ailments. In the absence of systemic studies in the literature, the present study was designed to evaluate the hypoglycemic, hypolipidemic and antioxidant properties of Lippia nodiflora leaves extract in alloxan-induced experimental diabetic rats. The beneficial effects of oral administration of Lippia nodiflora leaves extract (400 mg/kg b.w.) on the levels of biochemical parameters were determined in experimental groups of rats. The altered levels of biochemical parameters such as blood glucose, insulin and glycosylated hemoglobin in the diabetic rats were significantly reverted back to near basal values by the administration of Lippia nodiflora leaves extract to diabetic rats for 30 days. The levels of lipid peroxides in the plasma and pancreatic tissues of diabetic rats were elevated significantly and were normalized by the administration of Lippia nodiflora leaves extract. The activities of pancreatic enzymic antioxidants and the levels of plasma non-enzymic antioxidants were markedly declined in the diabetic rats. Upon treatment with Lippia nodiflora leaves extract to diabetic rats, these decreased levels were elevated to near normal values. The altered levels of lipid profile were reverted back to near normalcy upon the extract treatment. The results of the study indicate that Lippia nodiflora leaves extract possesses antilipidemic, antioxidant effects in addition to antidiabetic activity. The results are comparable with gliclazide, an oral standard hypoglycemic drug. The phytochemicals present in the Lippia nodiflora leaves may account for the observed pharmacological properties.

Keywords

Lippia nodiflora, Hypoglycemic, Hypolipidemic, Antioxidant Nature, Alloxan.
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  • Biochemical Evaluation of Hypoglycemic, Hypolipidemic and Antioxidant Properties of Lippia nodiflora Leaves Studied in Alloxan-Induced Experimental Diabetes in Rats

Abstract Views: 235  |  PDF Views: 2

Authors

S. Subramanian
Department of Biochemistry, University of Madras, Guindy Campus, Chennai - 600 025, Tamil Nadu, India
N. Priya
Department of Biochemistry, University of Madras, Guindy Campus, Chennai - 600 025, Tamil Nadu, India
V. Thamizhiniyan
Department of Biochemistry, University of Madras, Guindy Campus, Chennai - 600 025, Tamil Nadu, India

Abstract


Lippia nodiflora, a perennial herb, has been reported to possess a number of pharmacological activities and used for various ailments. In the absence of systemic studies in the literature, the present study was designed to evaluate the hypoglycemic, hypolipidemic and antioxidant properties of Lippia nodiflora leaves extract in alloxan-induced experimental diabetic rats. The beneficial effects of oral administration of Lippia nodiflora leaves extract (400 mg/kg b.w.) on the levels of biochemical parameters were determined in experimental groups of rats. The altered levels of biochemical parameters such as blood glucose, insulin and glycosylated hemoglobin in the diabetic rats were significantly reverted back to near basal values by the administration of Lippia nodiflora leaves extract to diabetic rats for 30 days. The levels of lipid peroxides in the plasma and pancreatic tissues of diabetic rats were elevated significantly and were normalized by the administration of Lippia nodiflora leaves extract. The activities of pancreatic enzymic antioxidants and the levels of plasma non-enzymic antioxidants were markedly declined in the diabetic rats. Upon treatment with Lippia nodiflora leaves extract to diabetic rats, these decreased levels were elevated to near normal values. The altered levels of lipid profile were reverted back to near normalcy upon the extract treatment. The results of the study indicate that Lippia nodiflora leaves extract possesses antilipidemic, antioxidant effects in addition to antidiabetic activity. The results are comparable with gliclazide, an oral standard hypoglycemic drug. The phytochemicals present in the Lippia nodiflora leaves may account for the observed pharmacological properties.

Keywords


Lippia nodiflora, Hypoglycemic, Hypolipidemic, Antioxidant Nature, Alloxan.

References