Research Journal of Pharmacology and Pharmacodynamics

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Amelioration of Gastric Lesions by Avocado (Persea americana) Fruit Extract on Indomethacin as well as Ethanol Induced Ulcerated Experimental Rats


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1 Department of Chemistry, Mizan-Tepi University, P. O. No 121, Tepi, East Africa, Ethiopia
     

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In the present study, anti-ulcerogenic potential of Avocado fruit extract was evaluated using two different models of gastric lesions induced in experimental rats; 1) Indomethacin-induced gastric lesions and 2) Ethanol-induced gastric lesions. Pretreatment with oral administration of the extract of Avocado fruit extract (300 mg/kg) prevented the formation of acute gastric lesion induced by both the experimental models: further, treatment with the ethanolic extract of Avocado fruit extract for a period of 15 days significantly reduced the ulcer index, ulcerated surface and significantly elevated the levels of glycoprotein contents in gastric juice.

Keywords

Avocado, Anti-Ulcerogenic Effect, Indomethacin-Induced Gastric Lesion, Ethanol-Induced Gastric Lesion, Ulcer Index.
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  • Amelioration of Gastric Lesions by Avocado (Persea americana) Fruit Extract on Indomethacin as well as Ethanol Induced Ulcerated Experimental Rats

Abstract Views: 294  |  PDF Views: 2

Authors

U. S. Mahadeva Rao
Department of Chemistry, Mizan-Tepi University, P. O. No 121, Tepi, East Africa, Ethiopia
Bizuneh Adinew
Department of Chemistry, Mizan-Tepi University, P. O. No 121, Tepi, East Africa, Ethiopia

Abstract


In the present study, anti-ulcerogenic potential of Avocado fruit extract was evaluated using two different models of gastric lesions induced in experimental rats; 1) Indomethacin-induced gastric lesions and 2) Ethanol-induced gastric lesions. Pretreatment with oral administration of the extract of Avocado fruit extract (300 mg/kg) prevented the formation of acute gastric lesion induced by both the experimental models: further, treatment with the ethanolic extract of Avocado fruit extract for a period of 15 days significantly reduced the ulcer index, ulcerated surface and significantly elevated the levels of glycoprotein contents in gastric juice.

Keywords


Avocado, Anti-Ulcerogenic Effect, Indomethacin-Induced Gastric Lesion, Ethanol-Induced Gastric Lesion, Ulcer Index.

References