Research Journal of Pharmacology and Pharmacodynamics

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An Experimental Evaluation of Anticonvulsant Activity of Ethanolic Extract of Seeds of Holarrhena antidysenterica in Mice


Affiliations
1 Department of Pharmacology, Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati, Assam, India
2 Department of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar, Maharashtra, 413736, India
3 Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Maharashtra, India
4 Department of Pharmacology, NSHM, College of Pharmaceutical Technology, Kolkata, India
     

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In present study the anticonvulsant activity of ethanolic extract of Holarrhena antidysenterica was carried out in swiss albino mice. The anticonvulsant activity of ethanolic extract of seeds of Holarrhena antidysenterica (250 and 500 mg/kg, p.o.) in mice was assessed by using maximum electroshock seizure (MES) test, pentylenetetrazol (PTZ), and bicuculine (BC) test. The ethanolic extract of H. antidysenterica significantly reduced the duration of seizures induced by maximal electroshock (MES). The ethanol extract in doses of 250 and 500 mg/kg conferred protection (17 and 50%, respectively) on the mice. The same doses also protected animals from tonic seizures induced by Pentylenetetrazol and significantly delayed the onset of tonic seizures produced by Pentylenetetrazol. The extract had no effect on bicuculine induced seizure. The ethanolic extract of H. antidysenterica (EEHA) reduced MES, PTZ induced convulsions.

Keywords

Anticonvulsant, H. antidysenterica, MES, PTZ, BC.
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  • An Experimental Evaluation of Anticonvulsant Activity of Ethanolic Extract of Seeds of Holarrhena antidysenterica in Mice

Abstract Views: 235  |  PDF Views: 2

Authors

Jiban Debnath
Department of Pharmacology, Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati, Assam, India
Santosh B. Dighe
Department of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar, Maharashtra, 413736, India
Nachiket S. Dighe
Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Maharashtra, India
Supriya Mana
Department of Pharmacology, NSHM, College of Pharmaceutical Technology, Kolkata, India

Abstract


In present study the anticonvulsant activity of ethanolic extract of Holarrhena antidysenterica was carried out in swiss albino mice. The anticonvulsant activity of ethanolic extract of seeds of Holarrhena antidysenterica (250 and 500 mg/kg, p.o.) in mice was assessed by using maximum electroshock seizure (MES) test, pentylenetetrazol (PTZ), and bicuculine (BC) test. The ethanolic extract of H. antidysenterica significantly reduced the duration of seizures induced by maximal electroshock (MES). The ethanol extract in doses of 250 and 500 mg/kg conferred protection (17 and 50%, respectively) on the mice. The same doses also protected animals from tonic seizures induced by Pentylenetetrazol and significantly delayed the onset of tonic seizures produced by Pentylenetetrazol. The extract had no effect on bicuculine induced seizure. The ethanolic extract of H. antidysenterica (EEHA) reduced MES, PTZ induced convulsions.

Keywords


Anticonvulsant, H. antidysenterica, MES, PTZ, BC.

References