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Memory Enhancing Property of Santalum album L. on Mice


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1 Padmavathi College of Pharmacy and Research Institute, Dharmapuri, Tamilnadu, India
     

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A lot of medicinal plants, traditionally used for thousands of years, are present in a group of herbal preparations of the Indian traditional health care system (Ayurveda) named Rasayana proposed for their interesting anti-oxidant activities. But the recent study suggests that herbal drugs have a complex pathology to cure Alzheimer's disease. Alzheimer's disease is an age related neuro degenerative condition associated with cognitive. Among the different plants, one of them has been specially investigated that they have the Anti-oxidant property. A number of plants constitute the Anti-oxidant activity, in which one of them is "Santalum album L." . It was described in one of the siddha system that S. album possesses the property of increasing the memory and cognitive. And also in the Ayurvedic formulation Smruthi leha also described that S.album having the property to decrease dementia in older people. Male albino mice of weighing around 15-20 gm which are one month old were taken for study. The mice were divide into seven groups, in each group a minimum of six animals are taken. They are induce with β-amyloid protein for memory loss. These memory lossed animals are treated with the alcoholic extract of Santalum album L. for a period of 30 days. Then the enzyme estimation is performed on these mice. The results shows that the Santalum album has the property of increased enzyme levels. That it gives the conclusion that Santalum album L. is having the memory enhancing property.
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  • J.B. McGraw, M.A. Furedi, Deer browsing and population viability of a forest understudy plant, science 307 (2005) 920-922.
  • V.Glaser, Billion-Dollor Market, blossoms as Botanical take ischolar_main, Nat. Biotechnol 17 (1999) 17-18.
  • Shani, K.C., 1998. The book of Indian tress. Bombay Natural History Scociety. Oxford University Press, Mumbai.
  • Kirtikar.K.R. Basu..B.D., 1993. In; Blatter.E. Caius.J.F., Mhaskar.K.S.(Eds). Indian Medicinal Plants. Vol III. Lalit Mohan Basu, Allahabad, India.
  • Nadkarni,K.M., 1993b. India Materia Medica. Popular Prakashan Pravite.Bombay.
  • G.Williamson, C.monach, Bioavailability & Bioefficacy of polyphenols in humans:II Review of 93 intervention studiews, Am.J.Clin. Nutrl. 81. (Suppl.1) (2005) 243s-255s.
  • R.J.Williams, J.P.Spencer, C.Rice-Evans, Flavanoids; antioxidant or signaling molecules: Free radical Bio.Med.36 (2004) 839-849.
  • M.K. Ang-lee, J.Mass, C.S.Yuan, Herbal Medicinines & Preparative Care, JAMA 286(2001) 208-216.
  • M.J. howea, N.S.Perry, P.J.Houghton, Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other Cognitive disorders, Phtother. Res 17 (2003) 1-18.
  • M.J.Howes, P.J.Houghton, Pants used in Chinese and Indian Traditional Medicine for Improvement of memory and cognitive Function, Pharmacol, Biochem. Behav 75 (2003) 513-527.
  • Banerjee,S., Evcavade.A., Rao. Ar., 1993. Modulatory influence of Sandalwood oil, on mouse hepatic Glutathione-S-Transeferase activity and acid soluble Sulphyl dryl level. Cancer letters 68. 105-109.
  • J.Raskin, D.M.Ribihicky. S. Komamytsky, N.lic. A.Povely, N.Borisjuk, A.Brinker, D.A.Mareno, C.Ripoll, N.Yakob, T.cornwell, B.Fridlender, Plants and Human Health in the Twenty First Century, Trends Biotech.20 (2002) 522-531.
  • Cummings JL. 2004. Alzheimer's disease. N. Engl. J. Med.351 56-67.
  • Wisniewski KE, Sisniewski HM, Wen G.Y. Occurrence of Neuropathological changes and dementia if Alzheimier's disease in Drown's Syndrome. Ann Neuro 1985; 17; 278-82.
  • Guzo, Cupples LA, Kurz A, et al., Head injury and the Risk of AD in the MIRIGE Study. Neurology 2000; 54 ; 1316-23.
  • M.P:Dementia in Developing Countries (Guest Editorial). International Psychogeriatrics 2001; 13; 389-393.
  • Group TDR: Dementia in Developing Countries. A preliminary consensus, statement from the 10/66 Dementia research Group. International Journal of Geriatic Psychiatry 2000: 15: 14-20.
  • Group TDR: Alzheimer's disease. International. 2007 [http://www.wlz.co.uk/1066].
  • Petel V, Prince M: Aging and Mental Health in a developing country; who cares? Qualitative studies from Goa, India. Psychological Medicine 2001, 31: 29-38.
  • Chandra, V., Ganguli, M, Pandav,R., et al (1998) Prevalence of Alzheimer's disease and other Dementias in Rural India: Indo-US study. Neurology,51 1000-1008.
  • WHO (1992) The ICD 10 Classification of mental and behavioral Disorders. Clinical Description and Diagnostic Guidelines. Geneva: WHO.
  • Vas, C.J., Pinto, c., Panikker,d., et al (2001) prevalence of Dementia in Urban Population. International Psychogeriatics, 13, 439-450.
  • Raj Kumar,S. & Kumar,S.(1996) Prevalence of dementia in the community a rural urban comparison from Madras, India . Australian Journal of ageing, 15, 9-13.
  • S. Shaji., Srija Base., and Abraham Verghese., et al. Prevalence of dementia in an Uraban Population in Kerala, India, British Journal of Psychiatry (2005), 186, 136-140.
  • Jeffreyl. Cummings,MD and Donna L. Masterman MD. Assesment of treatment associated changes in Behavior and Cholinergic Therapy of Neuropsychiatric symptoms in AD's - J. Clin Psychiatry 1998 (suoo II3): 23-30.
  • D.A. Butterfield, J.Drake, C.Pocernich, A. Castegan, Evidence of oxidative damage in AD's brain, Central role of amyloid beta-peptide, Trends Mol Med.7 (2001) 548-554.

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  • Memory Enhancing Property of Santalum album L. on Mice

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Authors

S. Papaiah
Padmavathi College of Pharmacy and Research Institute, Dharmapuri, Tamilnadu, India
V. Ranjith Babu
Padmavathi College of Pharmacy and Research Institute, Dharmapuri, Tamilnadu, India
T. Sivanageswara Rao
Padmavathi College of Pharmacy and Research Institute, Dharmapuri, Tamilnadu, India
D. D. Jackson
Padmavathi College of Pharmacy and Research Institute, Dharmapuri, Tamilnadu, India
K. L. Senthilkumar
Padmavathi College of Pharmacy and Research Institute, Dharmapuri, Tamilnadu, India

Abstract


A lot of medicinal plants, traditionally used for thousands of years, are present in a group of herbal preparations of the Indian traditional health care system (Ayurveda) named Rasayana proposed for their interesting anti-oxidant activities. But the recent study suggests that herbal drugs have a complex pathology to cure Alzheimer's disease. Alzheimer's disease is an age related neuro degenerative condition associated with cognitive. Among the different plants, one of them has been specially investigated that they have the Anti-oxidant property. A number of plants constitute the Anti-oxidant activity, in which one of them is "Santalum album L." . It was described in one of the siddha system that S. album possesses the property of increasing the memory and cognitive. And also in the Ayurvedic formulation Smruthi leha also described that S.album having the property to decrease dementia in older people. Male albino mice of weighing around 15-20 gm which are one month old were taken for study. The mice were divide into seven groups, in each group a minimum of six animals are taken. They are induce with β-amyloid protein for memory loss. These memory lossed animals are treated with the alcoholic extract of Santalum album L. for a period of 30 days. Then the enzyme estimation is performed on these mice. The results shows that the Santalum album has the property of increased enzyme levels. That it gives the conclusion that Santalum album L. is having the memory enhancing property.

References