Research Journal of Pharmacology and Pharmacodynamics

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Effect of Allium sativum in Immoblilization Stress Induced Albino Rats


Affiliations
1 Department of Pharmacy, Singhania University, Rajasthan, India
2 Luqman College of Pharmacy, Gulbarga, Karnataka, India
     

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The present study was carried out to evaluate the effect of ethanolic extract of Allium sativum (Alliceae) on immobilization stress induced albino rats. The effect was assessed by estimation of various biochemical parameters like glucose, cholesterol, triglycerides and blood urea nitrogen (BUN), and by determining the weight of organ such as, liver, spleen, testes, adrenal gland, blood cell count (WBC) and also the differential count at a dose of 200 mg/kg body weight per oral. The extract showed significant (p<0.001) decrease in blood glucose, cholesterol, triglyceride and BUN and also decreased the weight of organs. It also showed a significant (p<0.05) decrease in weight of adrenal gland. A significant (p<0.01) decrease in WBC count, polymorphs and monocytes and decrease in lymphocytes (p<0.05) and eosinophils was observed, compared to control group. Thus the obtained results revealed that the Allium sativum has got a significant anti stress activity.

Keywords

Immobilization Stress, Allium sativum, Cortisol, WBC, BUN.
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  • Effect of Allium sativum in Immoblilization Stress Induced Albino Rats

Abstract Views: 256  |  PDF Views: 2

Authors

S. Roshan
Department of Pharmacy, Singhania University, Rajasthan, India
Abdullah Khan
Department of Pharmacy, Singhania University, Rajasthan, India
Sadath Ali
Luqman College of Pharmacy, Gulbarga, Karnataka, India
B. Tazneem
Luqman College of Pharmacy, Gulbarga, Karnataka, India

Abstract


The present study was carried out to evaluate the effect of ethanolic extract of Allium sativum (Alliceae) on immobilization stress induced albino rats. The effect was assessed by estimation of various biochemical parameters like glucose, cholesterol, triglycerides and blood urea nitrogen (BUN), and by determining the weight of organ such as, liver, spleen, testes, adrenal gland, blood cell count (WBC) and also the differential count at a dose of 200 mg/kg body weight per oral. The extract showed significant (p<0.001) decrease in blood glucose, cholesterol, triglyceride and BUN and also decreased the weight of organs. It also showed a significant (p<0.05) decrease in weight of adrenal gland. A significant (p<0.01) decrease in WBC count, polymorphs and monocytes and decrease in lymphocytes (p<0.05) and eosinophils was observed, compared to control group. Thus the obtained results revealed that the Allium sativum has got a significant anti stress activity.

Keywords


Immobilization Stress, Allium sativum, Cortisol, WBC, BUN.

References