Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Vector Control Activity Studies on the Leaf of Zyziphus mauritiana


Affiliations
1 Dept. of Pharmacognosy, Nalanda College of Pharmacy, Nalgonda AP, India
2 Nalanda College of Pharmacy, Nalgonda, A.P., India
     

   Subscribe/Renew Journal


The present study was undertaken to evaluate anthelmintic and larvicidal activity of crude ethanolic leaf extract of Zyziphus mauritiana belonging to family Rhamnaceae. Through the preliminary chemical tests it was found that the plant is rich in flavonoids, phenols, steroids and tannins. Pheretima posthuma was used as the test worms. Various concentrations of ethanolic extracts were tested in the anthelmintic screening, which involved determination of time of paralysis (P) and time of death (D) of the worms. Piperazine citrate was included as standard reference and distilled water as control. In the case of larvicidal activity the study was conducted on Culex quniquefasicatus species of mosquito larvae and the rate of larval mortality was calculated. The results indicated that the crude ethanolic extract significantly demonstrated paralysis and also caused death of the helminth especially at higher concentration of 50 mg/ml, as compared to standard reference piperazine citrate. Similarly very optimistic results were observed for Culex quniquefasicatus species of mosquito larvae and LC50 value was calculated as 54.9658.

Keywords

Antihelmintic, Larvicidal, Zyziphus mauritiana, Pheretima Posthuma, Culex quniquefasicatus.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Reddy. KN, Patnayak, Reddy CS, Raju VS, Traditional Knowledge on wild food plants in Andhra Pradesh, Indian Journal of Traditional Knowledge, Volume 6 (1), 2007; 223.

  • Anonymous, Census of India 2001, Directorate of Census operations, Registrar General of India, New Delhi 2001; 586.

  • Sachchidananda, Prasad, Encyclopedic profile of Indian Tribes, Volume 3, Botanical Survey of India, Calcutta, 1996.

  • Nadkarni .KM, Indian Plants and drugs with their medicinal properties and uses, Edition, Srishiti Books, 2006; 420,298.

  • Leslie Taylor,The Healing Power Of Rainforest Herbs,first edition,Square One Publishers, New York, USA, 2005; 224.

  • Morton, J. Indian Jujube. In Fruits of warm climates. Julia F. Morton, Miami, FL". Department of Horticulture and Landscape Architecture at Purdue University. 1999; p. 272-275.

  • Loveness K. Nyanga, Martinus J.R. Nout, Tendekayi H. Gadaga, Bart Theelen, Teun Boekhout and Marcel H. Zwietering, Microbiological and Biochemical Properties of masau, Plant Foods and Hum Nutr. 1999; 59(7),19.

  • Lamien-Meda A, Polyphenol content and antioxidant activity of fourteen wild edible fruits from Burkina Faso. Molecule, 2008; 6;13(3):581-94.

  • Bhargava, Shukla, Chauhan, Vashishtha and G. Dhandar Impact of hybridity on flavonoid spectrum of ber (Ziziphus mauritianaLamk.)Environmental and Experimental Botany, Volume 53, Issue 2, April 2005, p 135-138.

  • Cisse A, Ndiaye A, Lopez-Sall P, Seck F, Faye B, Faye B.Antidiabetic activity of Zizyphus mauritiana Lam (Rhamnaceae),Dakar Med. 2000;45(2):105-7.

  • Dahiru. D, Sini J. M and John-Africa L. Antidiarrhoeal activity of Ziziphus mauritiana ischolar_main extract in rodents AfricanJournal of Biotechnology Vol. 5 (10), 2006; 941-945.

  • Sena LP, Vanderjagt, Analysis of nutritional components of eight famine foods of the Republic of Niger, Plant Foods and Hum Nutr. 1998; 52(1):17-30.

  • Harborne.J.B, "Phytochemical Methods", A Guide to Modern Techniques of Plant Analysis, 3rd edition, Springer (INDIA) Pvt. Ltd., New Delhi, 1998, 124-126.

  • Khandelwal.K.R, Practical pharmacognosy, first edition, Nirali prakashan, Pune India 2005, 27-35.

  • Ajaiyeoba E. O., Onocha P. A and Olarenwaju. In-vitro anthelmintic properties of Buchholzia coiaceae and Gynandropsis gynandra extract. Pharm. Biol. 39(3), 2001, 217-20.

  • Guidelines for laboratory and field testing of mosquito larvicides, W.H.O pesticide evaluation scheme 2005, 8-11.

  • Thorn G. W, Adams R. D, E. Braunwald, K. J. Isselbacher and R. G. Petersdorf. Harriasons Principles of Internal Medicine, McGraw Hill Co., New York, 1997, 1088.

  • Vigar.Z, Atlas of Medical Parasitology. P.G. Publishing House, Singapore, 1984, 216.

  • Chatterjee. K. D,Parasitology. Protozoology and Helminthology, Guha Ray Sree Saraswaty Press Ltd., Calcutta, 1967, 168-169.

  • ICMR Bulletin. Prospects of using herbal products in the control of mosquito vectors, vol 33(1) 2003, 1-10.


Abstract Views: 250

PDF Views: 0




  • Vector Control Activity Studies on the Leaf of Zyziphus mauritiana

Abstract Views: 250  |  PDF Views: 0

Authors

S. Sandhya
Dept. of Pharmacognosy, Nalanda College of Pharmacy, Nalgonda AP, India
S. A. H. Jafferi
Nalanda College of Pharmacy, Nalgonda, A.P., India
K. R. Vinod
Nalanda College of Pharmacy, Nalgonda, A.P., India
David Banji
Nalanda College of Pharmacy, Nalgonda, A.P., India
D. Narender Prasad
Nalanda College of Pharmacy, Nalgonda, A.P., India

Abstract


The present study was undertaken to evaluate anthelmintic and larvicidal activity of crude ethanolic leaf extract of Zyziphus mauritiana belonging to family Rhamnaceae. Through the preliminary chemical tests it was found that the plant is rich in flavonoids, phenols, steroids and tannins. Pheretima posthuma was used as the test worms. Various concentrations of ethanolic extracts were tested in the anthelmintic screening, which involved determination of time of paralysis (P) and time of death (D) of the worms. Piperazine citrate was included as standard reference and distilled water as control. In the case of larvicidal activity the study was conducted on Culex quniquefasicatus species of mosquito larvae and the rate of larval mortality was calculated. The results indicated that the crude ethanolic extract significantly demonstrated paralysis and also caused death of the helminth especially at higher concentration of 50 mg/ml, as compared to standard reference piperazine citrate. Similarly very optimistic results were observed for Culex quniquefasicatus species of mosquito larvae and LC50 value was calculated as 54.9658.

Keywords


Antihelmintic, Larvicidal, Zyziphus mauritiana, Pheretima Posthuma, Culex quniquefasicatus.

References