Research Journal of Pharmacology and Pharmacodynamics

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Management of Male Infertility by Neutraceutical: A Review


Affiliations
1 BM College of Pharmaceutical Education and Research, Indore (MP), India
2 Radharaman Institute of Pharmacy, Bhopal (M.P), India
3 Department of Pharmaceutics, Vels College of Pharmacy Chennai, (T.N), India
     

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Seminal oxidative stress in the male reproductive tract is known to result in peroxidative damage of the sperm plasma membrane and loss of its DNA integrity. Normally, a balance exists between concentrations of reactive oxygen species (ROS) and antioxidant scavenging systems. One of the rational strategies to counteract the oxidative stress is to increase the scavenging capacity of seminal plasma. Numerous studies have evaluated the efficacy of antioxidants in male infertility. In this review, the results of different studies conducted have been analyzed, and the evidence available to date is provided. We outline the role of nutritional and biochemical factors from the nutraceutical of anti oxidant class like lycopenes, selenium, folate, zinc, glutathiones, l-arginine, l-carnitine, coenzyme-Q, Vitamin E,Vitamin C,Vitamin B12 in reproduction and male infertility problem.

Keywords

Nutraceutical, Male Infertility, SOS, ROS, Antioxidants.
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  • Management of Male Infertility by Neutraceutical: A Review

Abstract Views: 268  |  PDF Views: 2

Authors

S. C. Shivhare
BM College of Pharmaceutical Education and Research, Indore (MP), India
Arjun O. Patidar
BM College of Pharmaceutical Education and Research, Indore (MP), India
K. G. Malviya
Radharaman Institute of Pharmacy, Bhopal (M.P), India
K. Venkatesh
Department of Pharmaceutics, Vels College of Pharmacy Chennai, (T.N), India
Kuldeep Rathod
Department of Pharmaceutics, Vels College of Pharmacy Chennai, (T.N), India

Abstract


Seminal oxidative stress in the male reproductive tract is known to result in peroxidative damage of the sperm plasma membrane and loss of its DNA integrity. Normally, a balance exists between concentrations of reactive oxygen species (ROS) and antioxidant scavenging systems. One of the rational strategies to counteract the oxidative stress is to increase the scavenging capacity of seminal plasma. Numerous studies have evaluated the efficacy of antioxidants in male infertility. In this review, the results of different studies conducted have been analyzed, and the evidence available to date is provided. We outline the role of nutritional and biochemical factors from the nutraceutical of anti oxidant class like lycopenes, selenium, folate, zinc, glutathiones, l-arginine, l-carnitine, coenzyme-Q, Vitamin E,Vitamin C,Vitamin B12 in reproduction and male infertility problem.

Keywords


Nutraceutical, Male Infertility, SOS, ROS, Antioxidants.

References