Research Journal of Pharmacology and Pharmacodynamics

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Influence of Coenzyme Q10 on Phenothiazine Induced Extrapyramidal Symptoms in Rats


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1 Department of Pharmacology, H.K.E Society's College of Pharmacy, Sedam Road, Gulbarga - 585105, Karnataka, India
     

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Single dose and multiple dose influence of, Coenzyme Q10 in chlorpromazine induced catatonia was studied in adults albino rats of either sex. The study intended to find the role of antioxidants coenzyme Q10 in controlling extrapyramidal side effects. Phenothiazine derivatives produce catatonia as an unwanted side effect when used especially for prolonged periods of time in psychiatric disorders. The catatonia was induced in albino rats using chlorpromazine in the dose of 0.9mg/200g p.o. and the degree of catatonia was recorded.

Coenzyme Q10 was administered first followed by chlorpromazine after 30 minutes p.o in single dose studies. In multiple dose studies Coenzyme Q10 was administered for 8 days followed by the combination of Coenzyme Q10 and chlorpromazine on 9th day as described above and the degree of catatonia was scored. The study reveals that coenzyme Q10 produced statistically significant reduction of extrapyramidal symptoms in both single and multiple dose studies. Thus coenzyme Q10 has beneficial effects in controlling the toxicity symptoms of phenothiazines. Since, coenzyme Q10 is used safely in the form of food supplement it can be recommended in patients who are using phenothiazine derivatives for prolonged periods of time.


Keywords

Chlorpromazine, Catatonia, Coenzyme Q10, Extrapyramidal Symptoms.
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  • Rang HP, Dale MM, Ritter JM, Moore PK. Antipsychotic drugs. Pharmacology, Churchill Livingstone Robert Stevenson House Edinburgh EH 1 3AF. 1999; 547-548.

  • Tripathi KD. Drugs used in mental illness: Antipsychotics and antianxity drugs. Essentials of Medical Pharmacology, Jaypee Brothers medical publishers (P) LTD, New Delhi 2008; 6th pp.423-433.

  • Reddick B, Stern TA. Catatonia, neuroleptic malignant syndrome,and serotonin syndrome. In:Stern TA, Herman JB, eds. Massachusetts General Hospital Psychiatry Update & Board Preparation, New York, NY: McGraw 217-224.

  • Hawkins JM, Archer KJ, Strakowski SM, et al. Somatic treatment of catatonia. Int J Psychiatry Med 1995; 25:345.

  • Fink M, Taylor MA. The many varieties of catatonia. Eur Arch Psychiatry Clin Neurosci 2001; 251(Suppl. 1):8-13.

  • Satyanarayan U, Chakrapani U. Free radicals and antioxidants. Essentials of Biochemistry, Books and Allied (P) Ltd. Kolkata 700010, 2nd Ed:pp. 351-354.

  • Hasan MY, Alshuaib WB, Singh S, Fahim ascorbic acid on lead induced alterations of synaptic transmission and contractile features in murine dorsiflexor muscle". Life Sci. 2003; 73 (8): 1017-25.

  • Huang J, Agus DB, Winfree CJ et al. " blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke the National Academy of Sciences 2001; 98 (20): 11720-4.

  • Ernster L, Dallner G. Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta 1271: 195-204, 1995.

  • Berbel-Garcia, A. et al. "Coenzyme Q 10 improves lactic acidosis, stroke like episodes, and epilepsy in a patient with melas". Clinical Neuropharmacology 2004; 27:187-191.

  • Damian MS. et al. "Coenzyme Q10 Combined With Mild Hypothermia After Cardiac Arrest". Heart Foundation 110: 3011-3016.

  • Folkers K. Basic chemical research on Coenzyme Q10 and integrated clinical research on therapy of diseases. In Lenaz G, ed. Coenzyme Q. New York : John Wiley and sons, 1985.

  • Kishi T, Makino K, Okamoto T, et al. Inhibition of myocardial respiration by psychotherapeutic drugs and prevention by Coenzyme Q. In: International of Symposium on Coenzyme Q. Biomedical and clinical aspects of Coenzyme Q. New York, NY: Elsevier Science Publishing Co; 1980(2): 139-157.

  • Satoh K, Sakagami H. Effect of metal ions on radical inte and cytotoxic activity of ascorbate. Anticancer Res 1997; 17:1125-1129.

  • Eipper BA, et al. "Peptidylglycine apha monooxygenase: a multifunctional pr processing,and routing domains". Protein Sci. 1993; 2 (4): 489-97.

  • Englard S, Seifter S. "The biochemical functions of ascorbic acid". Annu. Rev. Nutr. 1986; 6: 365-406.


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  • Influence of Coenzyme Q10 on Phenothiazine Induced Extrapyramidal Symptoms in Rats

Abstract Views: 256  |  PDF Views: 2

Authors

M. Nitin
Department of Pharmacology, H.K.E Society's College of Pharmacy, Sedam Road, Gulbarga - 585105, Karnataka, India
K. Prasad
Department of Pharmacology, H.K.E Society's College of Pharmacy, Sedam Road, Gulbarga - 585105, Karnataka, India
A. Dastapur
Department of Pharmacology, H.K.E Society's College of Pharmacy, Sedam Road, Gulbarga - 585105, Karnataka, India
S. Suryawanshi
Department of Pharmacology, H.K.E Society's College of Pharmacy, Sedam Road, Gulbarga - 585105, Karnataka, India

Abstract


Single dose and multiple dose influence of, Coenzyme Q10 in chlorpromazine induced catatonia was studied in adults albino rats of either sex. The study intended to find the role of antioxidants coenzyme Q10 in controlling extrapyramidal side effects. Phenothiazine derivatives produce catatonia as an unwanted side effect when used especially for prolonged periods of time in psychiatric disorders. The catatonia was induced in albino rats using chlorpromazine in the dose of 0.9mg/200g p.o. and the degree of catatonia was recorded.

Coenzyme Q10 was administered first followed by chlorpromazine after 30 minutes p.o in single dose studies. In multiple dose studies Coenzyme Q10 was administered for 8 days followed by the combination of Coenzyme Q10 and chlorpromazine on 9th day as described above and the degree of catatonia was scored. The study reveals that coenzyme Q10 produced statistically significant reduction of extrapyramidal symptoms in both single and multiple dose studies. Thus coenzyme Q10 has beneficial effects in controlling the toxicity symptoms of phenothiazines. Since, coenzyme Q10 is used safely in the form of food supplement it can be recommended in patients who are using phenothiazine derivatives for prolonged periods of time.


Keywords


Chlorpromazine, Catatonia, Coenzyme Q10, Extrapyramidal Symptoms.

References