Research Journal of Pharmacology and Pharmacodynamics

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Evaluation of Adaptogenic Activity of Moringa Oleifera Lam


Affiliations
1 M.M.U. College of Pharmacy, K. K. Doddi, Dist-Ramanagara-571511, Karnataka, India
     

   Subscribe/Renew Journal


Moringa oleifera Lam. (Moringaceae) is an medicinal plant used in the treatment of many clinical conditions in India. Its adaptogenic activity have been investigated in this study using albino mice and rats. The ethanolic extract of Moringa oleifera leaves was prepared and subjected to preliminary qualitative phytochemical screening. Glycosides, phytosterols, tannins and amino acids were found to be present. Acute toxicity studies were carried out in albino mice. The ethanolic extract did not show the lethal effect upto the doses of 2000mg/kg body weight with no signs of abnormalities or any mortality observed for 14 days period under observation after single dose of drug administration. The parameters studied were swimming endurance, cold-restraint induced ulcer, and effect of coldrestraint stress on adrenocortical activity and weights of organs like liver, spleen, adrenal glands. Geriforte was used as a standard adaptogenic drug, which is a commercial preparation of Himalaya Drugs Company. The results indicate that pretreatment with ethanolic extract of leaves of Moringa oleifera exhibited significant adaptogenic activity at the tested doses of 200 mg/kg and 400 mg/kg body weight. On the basis of results, it was concluded that Moringa oleifera possess adptogenic activity.

Keywords

Adaptogenic, Cold-Restraint Stress, Moringa oleifera, Swimming Endurance.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Selye H. The evaluation of the stress concept. Am Scientist. 1973; 61:692.

  • Tortora G J and Grabowski S R. Principles of anatomy and physiology. John Wiley. New York. 2003:620.

  • Brekhman I I and Dardymor I V. New substances of plant origin which increase nonspecific resistance. Ann Rev Pharmacol Toxicol. 1969; 9:419-430.

  • Kulkarni S K. Heat and other physiological stress induced analgesia: catecholamine mediated and naloxone reversible response. Life Sci. 1980; 27(3):185-188.

  • Wallace and Edward. Adaptogenic herbs: Natures solution to stress. Nutrition Science News. 1998; 3: 244.

  • Sastri B N. The Wealth of India- A dictionary of Indian Raw materials and industrial products: Council of Scientific and Industrial Research (CSIR), New Delhi. 1962; 1:425.

  • Nesamani S. Medicinal plants. State institute of Languages, Thiruvananthapuram. Kerala. 1999; 1:425.

  • Eilert U, Wolters B and Nahrstedt A. The antibiotic principle of seeds of Moringa oleifera and Moringa stenopetala. Planta Med. 1981; 42:55-61.

  • Dahot M U, Soomo Z H and Ashiq M. Pak J Pharmacol. 1997;14:15.

  • Dayrit F M, Alcanter A D and Villasenor I M. Philip J Sci. 1990; 119:23.

  • Faizi S, Siddiqui B S, Saleem R, Aftab K and Gilani A H. Isolation and structure elucidation of new nitrile and mustard oil glycosides from Moringa oleifera and their effect on blood pressure. J Nat Prod. 1994; 57:1251-1261.

  • Guevara A P and Vargas C. Anti-inflammatory and antitumor activities of seed extracts of malunggay, Moringa oleifera. Philip J Sci. 1996; 125:175-184.

  • Pal S K, Mukherjee P K and Saha B P. Studies on the antiulcer activity of Moringa oleifera leaf extract on gastric ulcer models in rats. Phytother Res. 1995; 9:463-465.

  • Kurma S R and Mishra S H. Anti-inflammatory and hepatoprotective activities of fruits of Moringa pterygosperma Gaerth. Ind J Nat Prod. 1998; 14:3-10.

  • Nadkarni K M and Nadkarni A K. Indian Materia Medica. Popular Prakashan Pvt. Ltd, India. 2005; 811-813.

  • Kokate C K. Practical pharmacognosy. Vallabh Prakashan. Delhi. 1994; 10-13:107-109.

  • Bhargava K P and Singh N. Antistress activity of Ocimum sanctum. Ind J Med Res. 1981; 73:443-451.

  • Senay E C and Levine R J. Synergism between cold and restraint for rapid production of stress ulcers in rats. Proc Soc Exptl Biol. 1967; 124:1221.

  • Selye H. A syndrome produced by various noxious agents. Nature. 1936; 138:32.

  • Mattingly D. A simple fluorimetric method for the study of free 11-hydroxy corticosteroids in human plasma. J Clin Patho. 1962; 15: 374-379.

  • Brekhman I I. Elecutherococcus senticosus; A new medicinal herb of the Araliaceae family. In Proceedings of second international pharmacological meeting. Pharmacology of oriental plans. Edited by Chen K K, Mukherji B and Volice L. Pergamon Press, Oxford. 1965; 7:97-102.

  • Lazarev N V. Farmacol Toxicol. 1958:21-81.

  • Eger W. Med Exptl. 1961; 4:251.

  • Singh R H, Malviya P C, Sarkar F H and Udupa K N. Studies on the psychotropic effect of Indian indigenous drug ashwagandha. Journal of Research in Indian Medicine, Yoga and Homeopathy. 1979; 14:49-59.

  • Miller T A. Mechanism of stress related mucosal damage. Am J Med. 1987; 83:8-14.

  • Djahanquiri B, Taubin H L and Landsburg L. Increased sympathetic activity in the pathogenesis of restraint ulcers in rats. J Pharmacol Exp Thera. 1973; 184:163-168.

  • Hooqerwerf W A and Pasricha P J. Agents used for control of gastric acidity and treatment of peptic ulcers and gastroesophageal reflux disease. In Goodman and Gilman’s. The pharmacological basis of therapeutics. Edited by Hardman J G and Limbird L E. Mc Graw-Hill, New York. 2001; 10th ed:1005-1019.

  • Guyton A. Medical physiology. Harcourt Brace jovonovich Inc. W B Saunders Co. 1991; 8th ed:848.

  • Paris J M, Lorens S A, Van de kar L D, Urban J H, Richardson Morton K D and Bethea C L. A comparison of acute stress paradigms: hormonal responses and hypothalamic serotonin. Physio Behaviour. 1987; 39:33-43.

  • Jacobson L and Sapolsky R M. The role of the hippocampus in the feedback regulation of the hypothalamic-pituitaryadrenocortical axis. Endocrine Rev. 1991; 12:118.

  • Sardesai S R, Abraham M E and Mascarenhas J F. Effect of stress on organ weight in rats. Ind J Physiol Pharmacol. 1993; 37 (2):104-108.


Abstract Views: 281

PDF Views: 2




  • Evaluation of Adaptogenic Activity of Moringa Oleifera Lam

Abstract Views: 281  |  PDF Views: 2

Authors

Shameer Pasha
M.M.U. College of Pharmacy, K. K. Doddi, Dist-Ramanagara-571511, Karnataka, India
Mohamed Khaleel
M.M.U. College of Pharmacy, K. K. Doddi, Dist-Ramanagara-571511, Karnataka, India
Sukhen Som
M.M.U. College of Pharmacy, K. K. Doddi, Dist-Ramanagara-571511, Karnataka, India

Abstract


Moringa oleifera Lam. (Moringaceae) is an medicinal plant used in the treatment of many clinical conditions in India. Its adaptogenic activity have been investigated in this study using albino mice and rats. The ethanolic extract of Moringa oleifera leaves was prepared and subjected to preliminary qualitative phytochemical screening. Glycosides, phytosterols, tannins and amino acids were found to be present. Acute toxicity studies were carried out in albino mice. The ethanolic extract did not show the lethal effect upto the doses of 2000mg/kg body weight with no signs of abnormalities or any mortality observed for 14 days period under observation after single dose of drug administration. The parameters studied were swimming endurance, cold-restraint induced ulcer, and effect of coldrestraint stress on adrenocortical activity and weights of organs like liver, spleen, adrenal glands. Geriforte was used as a standard adaptogenic drug, which is a commercial preparation of Himalaya Drugs Company. The results indicate that pretreatment with ethanolic extract of leaves of Moringa oleifera exhibited significant adaptogenic activity at the tested doses of 200 mg/kg and 400 mg/kg body weight. On the basis of results, it was concluded that Moringa oleifera possess adptogenic activity.

Keywords


Adaptogenic, Cold-Restraint Stress, Moringa oleifera, Swimming Endurance.

References