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Wound Healing Activity of Latex of Euphorbia nivulia Buch.-Ham. in Mice


Affiliations
1 Department of Biotechnology, SSBT's, College of Engineering and Technology, Bambhori, Post Box No. 94, NH - 6, Jalgaon: 425 001, Maharashtra, India
2 Department of Zoology, Moolji Jaitha College, Jalgaon: 425 002, Maharashtra, India
     

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Wound healing activity of Euphorbia nivulia Buch.-Ham. (Euphorbiaceae) was evaluated using excision wound model in albino mice by applying latex topically on the area of excised wound once a day for 23 days. Plant latex significantly enhanced the rate of wound contraction and period of epithelialization, which is comparable to Soframycin. Latex of this plant significantly reduces the bleeding and whole blood clotting time. Phytochemical analysis revealed the presence of alkaloids, cynogenic glycosides, phenolics, tannins and saponins. The latex of Euphorbia nivulia possesses natural ingredients capable of arresting wound bleeding and accelerating wound healing properties which suggests healing potential to cure wound.

Keywords

Bleeding Time, Euphorbia Nivulia, Excision Wound, Wound Healing.
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  • Habbu PV, Joshi H and Patil BS. Potential wound healers from plant origin. Pharmacognosy Review. 2007; 1(2): 271-282.

  • Chopda MZ, Mahajan RT. Wound healing plants of Jalgaon District, Maharashtra state, India. Ethanobotanical leaflets 2009; 13:1-32.

  • Kirtikar KR and Basu BD. Indian Medicinal Plants. Vol. IIV, International Book Distributors, Dehradun. 1995.

  • Mahajan RT and Badgujar SB. Ethnomedicinal values of Laticiferous plants used by tribal people of North Maharashtra, India. Research Link. 2008; 55, VII (8): 20-23.

  • Annapurna J, Chowdary IP, Lalitha G, Ramakrishna SV and Iyengar DS. Antimicrobial Activity of Euphorbia nivulia Leaf Extract. Pharmaceutical Biology. 2004; 42 (2): 91-93.

  • Veluri R, Reddy VLN, Reddy AV, Kodela R, Tadikamalla PR, Tejomoorty SR, Kondapi AK, Diwan PV and Yenamandra V. Three New Ingol Diterpenes from Euphorbia nivulia: Evaluation of Cytotoxic Activity, Chem. Pharm. Bull. 2003; 51(4): 431-434.

  • Sadaf F, Rubeena S, Muhammad A, Syed IA and Navaid-ul-Zafar. Healing potential of cream containing extract of Sphaeranthus indicus on dermal wounds in Guinea pigs. Journal of Ethnopharmacology. 2006; 107: 161-163.

  • Dacie JV and Lewis SM. Practical Haematology, 4th edition. J and H Churchill, London. 1970.

  • Okoli CO, Akah PA and Okoli AS. Potentials of use of Aspilia Africana (Compositae) in wound care: an experimental evaluation. BMC Complimentary and Alternative Medicine. 2007; 7: 24.

  • Wagner H, Bladt S and Zgainski EM. Plant Drug Analysis, 13th edition, Springer-Verlag, 1984.

  • Harborne JB. Phytochemical methods, A guide to modern techniques of plant analysis. Chapman and Hill, London. 1984.

  • Daniel WW. Biostatistics, A foundation for the analysis in the health sciences. 7th Edn., John Wiley and sons (Asia) Pvt Ltd, Singapore. 2004.

  • Nath LK and Dutta SK. Wound healing response of the proteolytic enzyme curcain. Indian Journal of Pharmacology. 1992; 24: 114-115.

  • Rasik AM, Shukla A, Patnaik GK, Dhawan BN, Kulshrestha DK and Srivastava S. Wound Healing Activity Of Latex Of Euphorbla Neriifolia Llnn. Indian Journal of Pharmacology. 1996; 28: 107-109.

  • Rasik AM, Ranghubir R, Gupta A and Jain HK. Wound healing potential of Calotropis procera on dermal wounds in guinea pigs. Journal of Ethnopharmacology. 1999; 68: 261-266.

  • Oduela T, Popoola1 GB, Avwioro OG, Oduola TA, Ademosun1 AA and Lawal MO. Use of Jatropha gossypifolia stem latex as a haemostatic agent: how safe is it? Journal of Medicinal Plants Research. 2007; 1 (1): 14-17.


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  • Wound Healing Activity of Latex of Euphorbia nivulia Buch.-Ham. in Mice

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Authors

S. B. Badgujar
Department of Biotechnology, SSBT's, College of Engineering and Technology, Bambhori, Post Box No. 94, NH - 6, Jalgaon: 425 001, Maharashtra, India
R. T. Mahajan
Department of Zoology, Moolji Jaitha College, Jalgaon: 425 002, Maharashtra, India
M. Z. Chopda
Department of Zoology, Moolji Jaitha College, Jalgaon: 425 002, Maharashtra, India

Abstract


Wound healing activity of Euphorbia nivulia Buch.-Ham. (Euphorbiaceae) was evaluated using excision wound model in albino mice by applying latex topically on the area of excised wound once a day for 23 days. Plant latex significantly enhanced the rate of wound contraction and period of epithelialization, which is comparable to Soframycin. Latex of this plant significantly reduces the bleeding and whole blood clotting time. Phytochemical analysis revealed the presence of alkaloids, cynogenic glycosides, phenolics, tannins and saponins. The latex of Euphorbia nivulia possesses natural ingredients capable of arresting wound bleeding and accelerating wound healing properties which suggests healing potential to cure wound.

Keywords


Bleeding Time, Euphorbia Nivulia, Excision Wound, Wound Healing.

References