Research Journal of Pharmacology and Pharmacodynamics

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Effect of Quisqualis indica Extract on Cholesterol Diet Induced Hyperlipidemia in Rats


Affiliations
1 Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari (Durg), Chhattisgarh, India
2 Siddhi Vinayak Institute of Technology and Science, Bilaspur, India
     

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Treatment of hyperlipidemia is important for prevention of many disease especially coronary heart diseases. It has been proven that 20% of all strokes and over 50% of all heart attacks can be linked to high fatty substances (cholesterol) and it can be reduced by increased dietary intake of antioxidants which is a vast source of plant extracts. In the present study the hypolipidemic activity of methanolic extracts of aerial parts of Quisqualis indica (QI) including flowers on cholesterol diet (PS) induced hyperlipidemia in rats had been evaluated. Hyperlipidemia was induced by cholesterol diet (dry coconut, milk powder etc.). The hypolipidemic activity was analyzed by reading the blood serum level in UV at 505 nm after treated with reagent present in auto span diagnostic kit. Dose of Methanolic extracts of QI had been prepared by using distilled water i.e. 100 mg/kg p.o and 200 mg/kg p.o. Methanolic extracts of QI significantly reduce the harmful lipid layer in blood serum at varying concentration which shows that the plant carries the hypolipidemic properties which was may be due to the inhibition of lipid peroxidation as the plants contain some active ingredients acting as antioxidants. Result shows that the plants extracts was more effective at 200 mg/kg whereas Atorvastatin (10mg/kg) drug is used as standard drug.

Keywords

Hypolipidemic, Hypocholesterolemic, Cholesterol Diet, Hyperlipidemia, Quisqualis indica, Coronary Heart Disease.
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  • Effect of Quisqualis indica Extract on Cholesterol Diet Induced Hyperlipidemia in Rats

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Authors

Sahu Jyoti
Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari (Durg), Chhattisgarh, India
Patel Pushpendra Kumar
Siddhi Vinayak Institute of Technology and Science, Bilaspur, India
Chanchal Deep Kaur
Shri Rawatpura Sarkar Institute of Pharmacy, Kumhari (Durg), Chhattisgarh, India

Abstract


Treatment of hyperlipidemia is important for prevention of many disease especially coronary heart diseases. It has been proven that 20% of all strokes and over 50% of all heart attacks can be linked to high fatty substances (cholesterol) and it can be reduced by increased dietary intake of antioxidants which is a vast source of plant extracts. In the present study the hypolipidemic activity of methanolic extracts of aerial parts of Quisqualis indica (QI) including flowers on cholesterol diet (PS) induced hyperlipidemia in rats had been evaluated. Hyperlipidemia was induced by cholesterol diet (dry coconut, milk powder etc.). The hypolipidemic activity was analyzed by reading the blood serum level in UV at 505 nm after treated with reagent present in auto span diagnostic kit. Dose of Methanolic extracts of QI had been prepared by using distilled water i.e. 100 mg/kg p.o and 200 mg/kg p.o. Methanolic extracts of QI significantly reduce the harmful lipid layer in blood serum at varying concentration which shows that the plant carries the hypolipidemic properties which was may be due to the inhibition of lipid peroxidation as the plants contain some active ingredients acting as antioxidants. Result shows that the plants extracts was more effective at 200 mg/kg whereas Atorvastatin (10mg/kg) drug is used as standard drug.

Keywords


Hypolipidemic, Hypocholesterolemic, Cholesterol Diet, Hyperlipidemia, Quisqualis indica, Coronary Heart Disease.

References