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A Review on Non-Steroidal Anti-Inflammatory Drugs Induced Kidney Diseases


Affiliations
1 Pharm D, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh., India
2 Pharm D, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh, India
3 Pharm D, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh
4 Associate Professor, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh., India
5 Principal, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh., India
     

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Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are used as over-the-counter drugs for Analgesic and Antiinflammatory conditions. They inhibit prostaglandins synthesis by acting on Cyclooxygenase enzymes in the Arachidonic cascade which causes various abnormal effects like peptic ulcers, Gastrointestinal bleeding, sodium and water retention, hypertension, hemodynamic kidney injury, nephrotoxicity, stroke, and myocardial infarction when used for a longer duration, especially in older patients/comorbidities patients/ pre-existing renal disease patients. This is because in older patients decrease in glomerular filtration rate and comorbidity conditions increase the risk of NSAIDs and cause Acute Kidney injury, Tubulointerstitial nephritis, and chronic kidney injury. NSAIDs do not cause much risk in patients who are young, without pre-existing kidney disease and without comorbidities. Physicians should educate patients with caution on the usage of NSAIDs for longer periods and should prescribe drugs in a dose-dependent manner.

Keywords

Nonsteroidal Anti-Inflammatory Drugs, Prostaglandins, Acute Kidney Injury, Tubulointerstitial Nephritis, Chronic Kidney Disease.
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  • A Review on Non-Steroidal Anti-Inflammatory Drugs Induced Kidney Diseases

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Authors

P. Pavani
Pharm D, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh., India
E. Naveena
Pharm D, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh, India
P. Subhashini
Pharm D, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh
S. Srikanth
Pharm D, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh., India
K. Thirumala Naik
Associate Professor, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh., India
M. Kishore Babu
Principal, Krishna Teja Pharmacy College, Tirupati, Andhra Pradesh., India

Abstract


Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are used as over-the-counter drugs for Analgesic and Antiinflammatory conditions. They inhibit prostaglandins synthesis by acting on Cyclooxygenase enzymes in the Arachidonic cascade which causes various abnormal effects like peptic ulcers, Gastrointestinal bleeding, sodium and water retention, hypertension, hemodynamic kidney injury, nephrotoxicity, stroke, and myocardial infarction when used for a longer duration, especially in older patients/comorbidities patients/ pre-existing renal disease patients. This is because in older patients decrease in glomerular filtration rate and comorbidity conditions increase the risk of NSAIDs and cause Acute Kidney injury, Tubulointerstitial nephritis, and chronic kidney injury. NSAIDs do not cause much risk in patients who are young, without pre-existing kidney disease and without comorbidities. Physicians should educate patients with caution on the usage of NSAIDs for longer periods and should prescribe drugs in a dose-dependent manner.

Keywords


Nonsteroidal Anti-Inflammatory Drugs, Prostaglandins, Acute Kidney Injury, Tubulointerstitial Nephritis, Chronic Kidney Disease.

References