Research Journal of Pharmacology and Pharmacodynamics

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Antidiabetic Activity in Aqueous Leaf Extract of Ciceracida Linn in Alloxan Induced Diabetes Rats Model


Affiliations
1 JJT University, Jhunjhunu, Rajasthan, India
2 Department of Pharmaceutical Science, JJT University, Jhunjhunu, Rajasthan, India
     

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Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostatis resulting in severe diabetic complication including retinopathy nephropathy, angiopathy, neuropathy due to perturbation in utilization of glucose. The present study was focused on antidiabetic effect of aqueous leaf extract of ciceracida (ALEC) in alloxan induced diabetic rats using Glibenclimide as a standard. The aqueous leaves extract of ciceracida administered at a dose of 100 mg/kg, 250 mg/kg and 500 mg/kg orally to the diabetic rats for 10 days in acute treatment group, whereas sub acute treatment for 30 days administration was done. In acute treatment group blood glucose level investigation was carried out on 4th, 7th and 10th day similarly in sub acute study animals were tested for blood glucose level on 14th, 21th and 30th day. Both acute and sub acute treatment groups shown reduction in elevated blood glucose level but sub acute treatment groups shown noticeable significant reduction in blood glucose level as compared with the control group. The study concluded that ALEC can be a new clinical significant choice in the treatment of diabetes.

Keywords

Ciceracida Leaf, Diabetes, Alloxon, Glibenclamide.
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  • Antidiabetic Activity in Aqueous Leaf Extract of Ciceracida Linn in Alloxan Induced Diabetes Rats Model

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Authors

Mohibul Hoque
JJT University, Jhunjhunu, Rajasthan, India
S. Satish
Department of Pharmaceutical Science, JJT University, Jhunjhunu, Rajasthan, India

Abstract


Diabetes mellitus is the most common endocrine disorder that impairs glucose homeostatis resulting in severe diabetic complication including retinopathy nephropathy, angiopathy, neuropathy due to perturbation in utilization of glucose. The present study was focused on antidiabetic effect of aqueous leaf extract of ciceracida (ALEC) in alloxan induced diabetic rats using Glibenclimide as a standard. The aqueous leaves extract of ciceracida administered at a dose of 100 mg/kg, 250 mg/kg and 500 mg/kg orally to the diabetic rats for 10 days in acute treatment group, whereas sub acute treatment for 30 days administration was done. In acute treatment group blood glucose level investigation was carried out on 4th, 7th and 10th day similarly in sub acute study animals were tested for blood glucose level on 14th, 21th and 30th day. Both acute and sub acute treatment groups shown reduction in elevated blood glucose level but sub acute treatment groups shown noticeable significant reduction in blood glucose level as compared with the control group. The study concluded that ALEC can be a new clinical significant choice in the treatment of diabetes.

Keywords


Ciceracida Leaf, Diabetes, Alloxon, Glibenclamide.

References