Preventive Neuroprotective Effect of Commonly Used Antihypertensive Drugs in Ischemic Cerebral Injury in Rats

Aim: Aim of this research was to find out possible use of well established antihypertensive drugs at their therapeutic doses, in prevention of ischemia and reperfusion induced cerebral injury. Methods: Male Wistar rats (200g - 250g) were subjected to 10 min bilateral common carotid artery occlusion, followed by 24 hour reperfusion. Antihypertensive drugs such as Amlodipine (1 mg/kg, oral) and Telmisartan (6 mg/kg, oral) and combination of both the drugs (1+6 mg/kg, oral) were used. All the drugs were administered for 7 days, till bilateral common carotid artery occlusion. Various behavioral parameters including Spatial memory, Locomotor activity, Balance and motor coordination) and biochemical parameters including Lipid peroxidtion, Superoxide dismutase activity were assessed. Results: Various behavioural and biochemical parameters (except Balance and motor coordination) were altered in control group. All drugs treated groups (as Amlodipine group, Telmisatran group and Combination group) have shown to exhibit nonsignificantly decrease in transfer latency time and nonsignificantly increase in locomotor activity, but significantly (P<0.05) increase in Superoxide dismutase (SOD) activity. Amlodipine and combination group exhibited non significantly decrease in lipid peroxidation. Conclusion: the data received from all experimental groups showed positive results in respect to neuroprotective effect in ischemic injury. This might be due to combined antioxidant effect. More study require to confirm neuroprotective effect.