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Hepatoprotective Activity of Prunus persica Peaches against Paracetamol Induced Hepatotoxicity


Affiliations
1 Dept. of Pharmacognosy, The Erode College of Pharmacy, Veppampalayam, Vallipurathan Palayam (PO), Erode – 638 112 Tamilnadu, India
2 The Erode College of Pharmacy, Tamilnadu, India
     

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Hepato- toxicity is a common toxicity happening during the treatment of chronic disease like tuberculosis, diabetics. Prunus persica belongs to Rosaceae is a plant growing in temperate region has laxative , sedative, anticancer property and also consist of glycosides, flavonoids, anthocyanins, vitamins. It also posses hepato-protactent property. To prove the activity scientifically the ethanolic extract of Prunus persica was studied against paracetamol induced hepatotoxicity in albino rats. The extract when evaluated at dose of 100mg/ kg was found to significantly reduce the elevated levels of serum lysosomal enzyme Sgpt, Sgot, Alp and Bilirubin when compared with standard silymarin.


Keywords

Prunus persica, Paracetamol, Albino Rats, Serum Enzymes.
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  • Hepatoprotective Activity of Prunus persica Peaches against Paracetamol Induced Hepatotoxicity

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Authors

S. Manokaran
Dept. of Pharmacognosy, The Erode College of Pharmacy, Veppampalayam, Vallipurathan Palayam (PO), Erode – 638 112 Tamilnadu, India
V. S. Saravanan
The Erode College of Pharmacy, Tamilnadu, India
Y. Bhargavi
The Erode College of Pharmacy, Tamilnadu, India

Abstract


Hepato- toxicity is a common toxicity happening during the treatment of chronic disease like tuberculosis, diabetics. Prunus persica belongs to Rosaceae is a plant growing in temperate region has laxative , sedative, anticancer property and also consist of glycosides, flavonoids, anthocyanins, vitamins. It also posses hepato-protactent property. To prove the activity scientifically the ethanolic extract of Prunus persica was studied against paracetamol induced hepatotoxicity in albino rats. The extract when evaluated at dose of 100mg/ kg was found to significantly reduce the elevated levels of serum lysosomal enzyme Sgpt, Sgot, Alp and Bilirubin when compared with standard silymarin.


Keywords


Prunus persica, Paracetamol, Albino Rats, Serum Enzymes.