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Development and Validation of Stability Indicating RP-HPLC Method for Estimation of Levamisole HCl in Bulk and Tablet Dosage Form
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A rapid, sensitive and accurate method for Estimation of Anti- Histamine in Tablet Dosage Form by RP-HPLC. Mobile phase was Methanol: 0.1% Ortho phosphoric acid (80:20% v/v). Flow rate was 0.9ml/min. The detection Wavelength was 227nm. The injection volume was 20-µl. The proposed method was validated for selectivity, precision, linearity, and accuracy. All validation parameters were within the acceptable range. Linearity studies for Levamisole was performed (10-60µg/ml). The %RSD for accuracy found to be less than2%. Assay was found to be 99.17 to 101.65 respectively The range of 10-60µg /ml was selected for the linearity of a standard Levamisole. The 80%, 100% and 120% levels of recovery study were selected to perform the recovery study.Linearity studies for Levamisole was performed on (10-60µg/ml).
Keywords
RP-HPLC, Levamisole, Methanol, Ortho Phosphoric Acid.
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