Evaluation of Manihot esculenta Tuber Starch as Tablet Binder

The purpose of the present study was to investigate the efficacy of Manihot esculents tuber starch as a disintegrant to paracetamol tablets at a concentration of 2-10%. The prepared tablets were evaluated for weight variation, thickness, hardness, uniformity, disintegration time and drug dissolution rate. The prepared tablets showed high disintegration and dissolution rate, because of its high swelling factor and low viscosity. The formulated tablet showed less disintegration time using extracted starch used as disintegrant. Dissolution studies showed the drug release from the prepared tablets containing 7.5-10%w/w was 80-90% in 1 hr. From the above results the extracted starch formulations showed good disintegrant and dissolution properties.