Formulation and Optimization of Metoprolol Succinate Sublingual Tablet by Statistical Optimization Technique

The purpose of the present research work was to prepare sublingual tablet, containing β1 Selective blocker Metoprolol succinate which suffers extensive first pass metabolism, prepared by using sublimation technique along with different polymers like Crosss povidone and menthol for emergency disease like hypertension, CHF (cardiac heart failure) and Angina.32 full factorial design applied for optimization of sublingual tablet and study the effect of processing parameters on disintegration time and friability. The tablets were evaluated for pre compressional parameters and quality control parameters along with characterization of DSC and FTIR Study. Conc. of menthol and crosss povidone shows impact on % D.T (9-30 sec.) and conc. of crosss povidone shows influence on % friability (0.325-0.609%). Tablets were pass out all precompressional parameters along with post compressional parameters like wetting time 18 sec. and drug content 101.06%. Dissolution study revealed that 95 % drug release within 5 minutes. By sublimation technique prepared tablets pass all the physico-chemical parameters. This formulation gives a wide range for the treatment of emergency disease like hypertension, angina and CHF.