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Sister Chromatid Exchanges in Peripheral Lymphocytes in Shoe Factory Workers Exposed to Organic Solvents


Affiliations
1 Human Genetics Laboratory, Department of Zoology, Osmania University, Hyderabad-500 007, A. P., India
 

Shoe manufacturing is an age-old profession in India. The genotoxic potential of organic solvents in cultured peripheral lymphocytes has been investigated on 62 male workers in a leather shoe factory located at IDA, Nacharam in Ranga Reddy district of Andhra Pradesh by using one of the recommended cytogenetic biomarkers. The blood samples were collected from male workers and 42 age matched controls. Analysis of sister chromatid exchanges in human peripheral lymphocytes was carried out in control and exposed groups. A significant increase in the percentage of SCEs was observed as compared to control. Thus, the study clearly reveals the mutagenic effect of organic solvents on human beings.

Keywords

Shoe Factory Workers, Organic Solvents, Sister Chromatid Exchanges, Peripheral Blood Lymphocytes.
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  • Sister Chromatid Exchanges in Peripheral Lymphocytes in Shoe Factory Workers Exposed to Organic Solvents

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Authors

K. Rudrama Devi
Human Genetics Laboratory, Department of Zoology, Osmania University, Hyderabad-500 007, A. P., India
S. Jithender Kumar Naik
Human Genetics Laboratory, Department of Zoology, Osmania University, Hyderabad-500 007, A. P., India

Abstract


Shoe manufacturing is an age-old profession in India. The genotoxic potential of organic solvents in cultured peripheral lymphocytes has been investigated on 62 male workers in a leather shoe factory located at IDA, Nacharam in Ranga Reddy district of Andhra Pradesh by using one of the recommended cytogenetic biomarkers. The blood samples were collected from male workers and 42 age matched controls. Analysis of sister chromatid exchanges in human peripheral lymphocytes was carried out in control and exposed groups. A significant increase in the percentage of SCEs was observed as compared to control. Thus, the study clearly reveals the mutagenic effect of organic solvents on human beings.

Keywords


Shoe Factory Workers, Organic Solvents, Sister Chromatid Exchanges, Peripheral Blood Lymphocytes.