Haemato-Biochemical Studies on Diclofenac, Ibuprofen and Nimesulide Induced Toxicity in Broilers

The present experimental work was conducted to elucidate the haemato-biochemical studies in broiler chicks when treated with diclofenac sodium, ibuprofen and nimesulide. For this study 120 apparently healthy broiler chicks of either sex were randomly divided into 10 groups comprising 10 birds in 9 groups and 30 birds in control group. The broilers of diclofenac groups were administered 10, 20 and 30 mg/kg body weight of diclofenac sodium for 5 days. Similarly the broilers of ibuprofen groups were administered with 15, 30 and 45 mg/kg body weight of ibuprofen with feed for 5 days. The birds of nimesulide groups were administered with 10, 20 and 30 mg/kg nimesulide for 5 days. The birds of control group were maintained on feed and plain water to serve as control. There was no significant difference in haematological parameters in birds which are intoxicated with diclofenac, ibuprofen and nimesulide. On the other hand there was significant difference in alkaline phosphatase and BUN biochemical parameters, but no significant difference in total protein and calcium intoxication in chicks.