The Effect of Selenium on the Blood Radioimmunological Indexes Induced by High Dose of Fluorine

Endemic fluorosis is prevalent in China, which can seriously impair the bones, teeth and cardiovascular system. The study was intended to explore antagonism of selenium (Se) on high dose fluorine (F) inducing plasma 6-Keto-prostaglandin F_1α, Thromboxane B₂ and Endothelin-1. Twenty male rabbits were randomly divided into 4 groups: High F group (NaF,100mg/L), Se group (Na₂SeO₃,1mg/L), High F + Se group (NaF,100mg/L; Na₂SeO₃,1mg/L) and Control group (without fluorine and selenium). The ear vein blood was collected for measurement of serum selenium and fluorine at the end of 0, 3^rd and 6_th months. At the end of 6th months, plasma 6-Keto-prostaglandin F_1α (6-K-P), Thromboxane B₂ (TXB₂) and Endothelin-1 (ET-1) were detected. Serum fluorine was increased in high F group and serum Se was increased in Se group. Plasma 6-K-P was decreased, while the plasma TXB₂ and ET-1 increased with the development of fluorosis. Compared with the high F group, the plasma 6-K-P was higher (p<0.01), whereas plasma TXB₂ and ET-1 were lower (p<0.01) in high F + Se group. The interaction showed that there was a significant antagonistic action of Se on decreased 6-K-P and increased TXB₂ induced by high dose fluorine. Our study showed that the Se may antagonize the adverse effects of high F.