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Niraimathi, V.
- Antimicrobial Activity of 2-Heteroaryl Substituted Quinazolones
Abstract Views :172 |
PDF Views:93
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, IN
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, IN
Source
Journal of Pharmaceutical Research, Vol 8, No 3 (2009), Pagination: 159-161Abstract
2-hetero substituted-4-quinazolone derivatives attract a wide spread interest due to the diverse biological activities. Six novel 2-heterosubstituted quinazolones were synthesized and the structures were assigned on the basis of spectral data. These compounds were screened for their antimicrobial activity. The recorded zone of inhibition showed significant broad spectrum antibacterial activity when compared with standard ciprofloxacin. Antifungal screening indicated that all the synthesized moieties had inhibitory effect against the tested pathogenic fungi.Keywords
Quinazolone, Antimicrobial Activity.- Estimation of Cefditoren Pivoxil in Pharmaceutical Oral Solid Dosage form by Spectrophotometry
Abstract Views :149 |
PDF Views:80
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai - 600 003, Tamil Nadu, IN
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai - 600 003, Tamil Nadu, IN
Source
Journal of Pharmaceutical Research, Vol 9, No 2 (2010), Pagination: 63-65Abstract
Four new, simple, sensitive and reproducible spectrophotometric methods have been developed for the estimation of cefditoren pivoxil in tablet dosage form. Method A involves the determination of cefditoren pivoxil by Standard absorbance method at 230nm and the Beer's concentration range was found to be 5-50 μg/mL. Method B and Method C involve the determination of cefditoren pivoxil by first derivative spectrophotometry and second derivative spectrophotometry respectively. The normal spectrum was derivatized to first and second order derivative spectrum and the linearity was found to lie within the Beer's range for cefditoren pivoxil. Method D involves the determination of cefditoren pivoxil by area under curve method and the linearity was established.Keywords
Cefditoren Pivoxil(CP), Beer's Law, Standard Absorbance Method, Derivative Spectrophotometry, Area under Curve(AUC).- Simultaneous Spectrophotometric Estimation of Telmisartan and Amlodipine in Tablet Dosage Form
Abstract Views :169 |
PDF Views:77
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, IN
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, Tamil Nadu, IN
Source
Journal of Pharmaceutical Research, Vol 9, No 3 (2010), Pagination: 137-140Abstract
Four new simple, accurate and precise spectrophotometric methods have been developed for simultaneous determination of telmisartan and amlodipine in pharmaceutical dosage form. Method A involves formation and solving of simultaneous equation using 299nm and 364nm as two wavelengths. Method B involves formation of Q-absorbance equation at 339nm (iso absorptive point) and at 299nm (λmax of telmisartan). Method C involves first order derivative method for simultaneous estimation of these two drugs. Method D involves the AUC for first order derivative spectrum. Both the drugs obey the Beer's law in the range 5-50μg/mL for amlodipine and 5-40μg/mL for telmisartan. The results of analysis have been validated statistically and by recovery studies.Keywords
Telmisartan (TEL), Amlodipine (AML), Simultaneous Equation, Q-Absorbance, Area Under Curve, Derivative Spectrophotometry.- Estimation of Acebrophylline in Pharmaceutical Oral Solid Dosage form by RP-HPLC
Abstract Views :166 |
PDF Views:69
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Madras Medical College, Chennai-600 003, IN
1 Department of Pharmaceutical Chemistry, Madras Medical College, Chennai-600 003, IN
Source
Journal of Pharmaceutical Research, Vol 9, No 3 (2010), Pagination: 115-116Abstract
A simple, specific and accurate reverse phase high performance liquid chromatographic method was developed for the estimation of acebrophylline in capsule dosage form. A phenomenex Gemini C18, 5μm column having 250×4.6mm i.d. in isocratic mode with mobile phase containing diammonium phosphate buffer (pH 4):methanol (60:40) was used. The flow rate was 1mL/minute and effluents were monitored at 273nm. The retention time was found to be 4.54 minutes. The linearity was in the range of 80-120 μg/mL. The proposed method was validated and successfully applied for the estimation of acebrophylline in capsule dosage form.Keywords
Acebrophylline(ACE), RP-HPLC.- Antimicrobial Study (Invitro) of Azomethines of Aryl Oxazoles
Abstract Views :202 |
PDF Views:78
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, IN
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-600 003, IN
Source
Journal of Pharmaceutical Research, Vol 10, No 2 (2011), Pagination: 83-84Abstract
A novel series of azomethines of aryl oxazoles were synthesised and investigated for their antimicrobial activity against Gram positive and Gram negative bacteria using antibiotic diffusion method. The recorded data of zone of inhibition showed significant broad activity when compared with standard. The sensitivity of the Gram positive bacteria to the tested compounds was higher than that of Gram negative bacteria. The synthesised compounds were also screened for antifungal activity and observed that they had an inhibitory effect against the pathogenic fungi.Keywords
Oxazoles, Azomethines, Antibacterial Activity, Antifungal Activity.- Antimicrobial Activity of Azomethines of Aryl Thiazole
Abstract Views :220 |
PDF Views:99
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-3, IN
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai-3, IN
Source
Journal of Pharmaceutical Research, Vol 10, No 2 (2011), Pagination: 85-86Abstract
Aryl thiazoles and their azomethines attract a wide spread interest due to the diversified biological activities. Five new azomethines of aryl thiazole were synthesised and the structure were assigned according to their spectral data. These compounds were screened for their antibacterial activity against both Gram positive and Gram negative organisms. The recorded zone of inhibition showed significant broad spectrum activity when compared with standard ciprofloxacin. Antifungal screening indicated that all the synthesised compounds had inhibitory effect against the tested pathogenic fungi.Keywords
Azomethines, Thiazoles, Antimicrobial Activity.- Estimation of Nisoldipine by RP-HPLC in Oral Solid Dosage Form
Abstract Views :188 |
PDF Views:86
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai–600 003, IN
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai–600 003, IN