Journal of Pharmaceutical Research

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Four new simple, accurate and precise spectrophotometric methods have been developed for simultaneous determination of telmisartan and amlodipine in pharmaceutical dosage form. Method A involves formation and solving of simultaneous equation using 299nm and 364nm as two wavelengths. Method B involves formation of Q-absorbance equation at 339nm (iso absorptive point) and at 299nm (λmax of telmisartan). Method C involves first order derivative method for simultaneous estimation of these two drugs. Method D involves the AUC for first order derivative spectrum. Both the drugs obey the Beer's law in the range 5-50μg/mL for amlodipine and 5-40μg/mL for telmisartan. The results of analysis have been validated statistically and by recovery studies.

Keywords

Telmisartan (TEL), Amlodipine (AML), Simultaneous Equation, Q-Absorbance, Area Under Curve, Derivative Spectrophotometry.
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