Determination of Degradation Product for Combination Containing Amoxicillin and Dicloxacillin in Capsule Dosage form by LC-MASS Spectroscopy

A study was carried out using LC-MASS Spectroscopy to determine the degradation products of formulation (capsules) containing Amoxicillin and Dicloxacillin. Previously an RP-HPLC method was performed to determine the stability of five batches of four different brands of formulation (capsules) containing Amoxicillin and Dicloxacillin which were expiring in consecutive months (7^th, 8^th, 9^th, 10^th and 12^th month of 2010). The Dicloxacillin content in all the five batches steadily decreased over the period of consecutive 5 month Assays (one month interval between each Assays), thereby determined the degradation product of Dicloxacillin by LC-MASS Spectroscopy.