Potential of Hydroalcoholic Extract of Tylophora indica Leaves for Antidiabetic Property in Rat

The present study was carried out to ascertain the role of hydroalcoholic extract of Tylophora indica leaves for its possible antidiabetic potentials in streptozotocin (STZ) induced diabetic Wistar female rats. A single intraperitoneal injection of STZ (55 mg/kg) elevated the glucose level>230 mg/dl after 3 days. Oral administration of the hydroalcoholic extract of Tylophora indica leaves at 100 and 250 mg/kg resulted in significant reduction (P<0.001) in blood glucose level. Body weight was significantly reduced (P<0.001) in STZ induced diabetic rats when compared to normal rats, while in diabetic rats Tylophora indica leaves extract (P<0.001) prevented significantly the decrease in body weight in a dose dependant manner. Total cholesterol, triglyceride, LDL-c and HDL-c levels were altered in STZ induced diabetic rats, which were considerably restored to near normal in animals treated with Tylophora indica extract. The administration of hydroalcoholic extract of Tylophora indica resulted in significant (P<0.001) increase in the levels of superoxide dismutase, catalase, glutahione peroxidase, glutathione-S-transferase and reduced glutathione, thus resulting in reduced free radical formation in liver tissues of the diabetic rat. These observations demonstrated the dose dependent antidiabetic effect of hydroalcoholic extract of Tylophora indica leaves in STZ-induced diabetic rat.