Journal of Pharmaceutical Research

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Objective: The main objective of our study is to see the hepatoprotective effect of Nigella sativain Cyclosporine induced hepatotoxicity in rats.

Methods: the effect of Nigella sativa on cyclosporine induced hepatotoxicity was studied in albino rats. The animals were divided into 3 groups with 6 rats in each group. Group I served as vehicle control, Group II animals were given Cyclosporine 25mg/Kg body weight orally for 21 days and Group III were given Cyclosporine 25mg/Kg + Nigella sativa 1ml/Kg body weight orally for 21 days. The blood samples were collected for liver enzymes estimation before and after the experiment. The animals were sacrificed on 22nd day and liver was subjected to histopathological examination.

Results: Cyclosporine provoked hepatotoxicity was evident from increase of hepatic enzyme levels and histopathological changes. Addition of Nigella sativa has resulted in the decrease of elevated hepatic enzyme levels and improvement in histopathological changes in liver.

Conclusion: The present study showed that Nigella sativa oil has protective effect on Cyclosporine induced hepatotoxicity in albino rats.


Keywords

Nigella sativa, Cyclosporine, Hepatotoxicity.
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