Synthesis and Biological Studies of some Novel Thiazolidinones

Pyridine-3-carboxylic acid hydrazide on condensation with substituted aromatic aldehydes yielded the benzylidine-arylidine acetohydrazido pyridine derivatives, (3a-3l) which on cyclization with thioglycolic acid in presence of anhyd. Zinc chloride as catalyst afforded phenyl-3-(Nicotinyl amino)-1, 3-thiazolidin-4-one derivatives (4a-4l). The structures of the newly synthesized compounds have been established on the basis of IR, MASS and 1H NMR spectral data. These compounds have also been screened for their biological activity.