Journal of Pharmaceutical Research

The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader).

If you would like more information about how to print, save, and work with PDFs, Highwire Press provides a helpful Frequently Asked Questions about PDFs.

Alternatively, you can download the PDF file directly to your computer, from where it can be opened using a PDF reader. To download the PDF, click the Download link above.

Fullscreen Fullscreen Off


This work was aimed at investigating diclofenac-β-cyclodextrin inclusion complexes in aqueous medium. Applying the method of phase solubility analysis, β-cyclodextrin formed a complex in 1:1 stoichiometry with diclofenac. The complex obeyed Beer's law. The stability constant, partition coefficient and solubility values were evaluated. The effect of pH on the stability of the complex was studied. The results indicated an increased aqueous solubility of diclofenac when complexed with β-cyclodextrin. Maximum stability of the complex was at pH value of 4.0. This makes it possible for aqueous oral solution of diclofenac to be formulated.

Keywords

Cyclodextrin, Inclusion Complex, Stability, Diclofenac, Phase Solubility.
User
Notifications
Font Size