Journal of Pharmaceutical Research

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Antiulcer Potential of Cucumis melo Var. Momordica (Roxb.), Duthie & Fuller Fruits in Experimental Animal


Affiliations
1 Department of Pharmaceutical Chemistry, United Institute of Pharmacy, Naini, Allahabad, India
2 Department of Pharmaceutical Sciences, SHUATS, Allahabad, India
 

Purpose: This study was aimed to evaluate the antiulcer potential of Cucumis melo var. momordica (Roxb.) Duthie&Fuller, fruits.

Methodology: Ethanol and pylorus ligation induced ulcer methods were used in rats for the study. The aqueous and ethanolic extracts (200 and 400 mg/kg body weight) were administered orally and effects on volume of gastric secretions, ulcer index, total and free acidity were evaluated.

Findings: A significant dose dependent reduction (P < 0.05) in the acid parameters like ulcer index, gastric volume, free and total acidity and elevation in pH were observed after treatment with 200 and 400 mg/kg extracts in Pylorus ligation and ethanol-induced ulcer models.This reduction in acid-secretary parameters and ulcer score suggesting that acid inhibition accelerates ulcer healing.

Conclusion: Based on our findings, we presume that the anti-secretary properties of both extracts were responsible for its anti-ulcer potency. These findings suggest the potential for use of Cucumis melo extract as an adjuvant in the treatment of gastric ulcer.


Keywords

Antiulcer, Cucumis melo Var. Momordica (Roxb.) Duthie & Fuller, Ethanolic Extract Pylorus Ligation.
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  • Antiulcer Potential of Cucumis melo Var. Momordica (Roxb.), Duthie & Fuller Fruits in Experimental Animal

Abstract Views: 203  |  PDF Views: 73

Authors

Arvind Kumar Srivastava
Department of Pharmaceutical Chemistry, United Institute of Pharmacy, Naini, Allahabad, India
Alok Mukerjee
Department of Pharmaceutical Chemistry, United Institute of Pharmacy, Naini, Allahabad, India
P. W. Ramteke
Department of Pharmaceutical Sciences, SHUATS, Allahabad, India
Himanshu Pandey
Department of Pharmaceutical Sciences, SHUATS, Allahabad, India
Shanti Bhushan Mishra
Department of Pharmaceutical Chemistry, United Institute of Pharmacy, Naini, Allahabad, India

Abstract


Purpose: This study was aimed to evaluate the antiulcer potential of Cucumis melo var. momordica (Roxb.) Duthie&Fuller, fruits.

Methodology: Ethanol and pylorus ligation induced ulcer methods were used in rats for the study. The aqueous and ethanolic extracts (200 and 400 mg/kg body weight) were administered orally and effects on volume of gastric secretions, ulcer index, total and free acidity were evaluated.

Findings: A significant dose dependent reduction (P < 0.05) in the acid parameters like ulcer index, gastric volume, free and total acidity and elevation in pH were observed after treatment with 200 and 400 mg/kg extracts in Pylorus ligation and ethanol-induced ulcer models.This reduction in acid-secretary parameters and ulcer score suggesting that acid inhibition accelerates ulcer healing.

Conclusion: Based on our findings, we presume that the anti-secretary properties of both extracts were responsible for its anti-ulcer potency. These findings suggest the potential for use of Cucumis melo extract as an adjuvant in the treatment of gastric ulcer.


Keywords


Antiulcer, Cucumis melo Var. Momordica (Roxb.) Duthie & Fuller, Ethanolic Extract Pylorus Ligation.

References