Journal of Pharmaceutical Research

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Solid Lipid Nanoparticles- An Innovative Approach for Improving the Solubility and Bioavailability


Affiliations
1 Department of Pharmaceutics, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Varthur Hobli, Bangalore - 560035, KA, India
 

Purpose: The purpose of this study is to give a general review on solid lipid nanoparticles (SLNs) as a novel drug carrier for improving the solubility and bioavailability of drugs.

Approach: Among the various colloidal drug carriers, SLNs have been emerged as next generation drug delivery system for incorporating lipophilic drugs. They are relatively nontoxic and nonirritant. The review insight on the various methods of preparation, characterization and also the application of SLNs for improving the solubility and bioavailability is explained here.

Findings: SLNs is used as a novel carrier for improving the solubility of poorly soluble drugs which may results in enhanced bioavailability and stability of drug can also be improved by incorporating drug in the form of solid lipid nanoparticles.

Conclusion: This review presents an overview of SLNs which includes SLN and its properties, excipients, techniques used in preparation of SLNs, characterization, and their applications.


Keywords

Bioavailability, Solubility, Lipophilic, Stability, Advantages, Disadvantages.
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  • Solid Lipid Nanoparticles- An Innovative Approach for Improving the Solubility and Bioavailability

Abstract Views: 174  |  PDF Views: 68

Authors

C. Akash
Department of Pharmaceutics, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Varthur Hobli, Bangalore - 560035, KA, India
Preethi Sudheer
Department of Pharmaceutics, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Varthur Hobli, Bangalore - 560035, KA, India
Bharani S. Sogali
Department of Pharmaceutics, Krupanidhi College of Pharmacy, #12/1, Chikkabellandur, Carmelaram Post, Varthur Hobli, Bangalore - 560035, KA, India

Abstract


Purpose: The purpose of this study is to give a general review on solid lipid nanoparticles (SLNs) as a novel drug carrier for improving the solubility and bioavailability of drugs.

Approach: Among the various colloidal drug carriers, SLNs have been emerged as next generation drug delivery system for incorporating lipophilic drugs. They are relatively nontoxic and nonirritant. The review insight on the various methods of preparation, characterization and also the application of SLNs for improving the solubility and bioavailability is explained here.

Findings: SLNs is used as a novel carrier for improving the solubility of poorly soluble drugs which may results in enhanced bioavailability and stability of drug can also be improved by incorporating drug in the form of solid lipid nanoparticles.

Conclusion: This review presents an overview of SLNs which includes SLN and its properties, excipients, techniques used in preparation of SLNs, characterization, and their applications.


Keywords


Bioavailability, Solubility, Lipophilic, Stability, Advantages, Disadvantages.

References