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Profile of Microvascular Complications in Newly Diagnosed Type 2 Diabetics and its Association with Correlates of Metabolic Syndrome in a Tertiary Hospital: An Observational Study


Affiliations
1 M.S. Ramaiah Medical College, MSR College Road, MSR Nagar, MSRIT Post, Mathikere, Bengaluru - 560054, KA, India
 

Aim: The primary objective was to study the profile of microvascular complications in newly diagnosed type 2 diabetics in a tertiary hospital and to determine its association with correlates of Metabolic Syndrome.

Settings and Design: This was a prospective observational study conducted over a period of six months among patients attending the Endocrinology outpatient of a tertiary care centre in a South Indian city.

Materials and Methods: We studied the correlation of microvascular complications (neuropathy, nephropathy, retinopathy and foot ulcers) in 44 newly diagnosed type 2 diabetics with associated risk factors i.e., hypertension, obesity and dyslipidemia.

Results: The prevalence of peripheral neuropathy, nephropathy and retinopathy was 15.9%, 2.3% and 2.3% respectively. The study showed that out of 44 patients, 18 had hypertension (40.91%). Four out of the 18 hypertensive patients had microvascular complications (22.2 %). There was a significant association between obesity and peripheral neuropathy (P< 0.05).

Conclusion: There was a maximum prevalence of peripheral neuropathy amongst the newly diagnosed diabetics thus they should be wary of the corresponding symptoms of numbness and tingling of feet. It was seen that out of the total 44 diabetic patients, 9.09% had both hypertension and microvascular complications. The low percentage is because 52% of the total hypertensives were on antihypertensive medication. There was also a significant association between obesity and neuropathy. Thus, those with obesity and hypertension are at a high risk of developing microvascular complications.


Keywords

Dyslipidemia, Obesity, Neuropathy, Metabolic Syndrome.
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  • Mohan V, Sandeep S, Deepa R, Shah B, Varghese C. Epidemiology of type 2 diabetes: Indian scenario. Indian J Med Res. 2007; 125: 217-30.

  • Kumar KPS,Bhowmik D, Srivastava S, Paswan S, Dutta AS. Diabetes Epidemic in India-- A Comprehensive Review of Clinical Features, Management and Remedies. The Pharma Innovation. 2012; 1:17-33.

  • Gupta A, Gupta AK, and Singh TP.Occurence of Complications in newly diagnosed type 2 diabetes patients: a hospital based study. J Indian Med Assoc 2013; 111:245-7.

  • Rahman S, Zia I. Prevalence of Microvascular Complications among Diabetic Patients. Pakistan J. Med. Res..2004; 43:1-3.

  • Shera AS, Jawad F, Maqsood A, Jamal S, Azfar M, Ahmed U. Prevalence of Chronic Complications and Associated Factorsin Type 2 Diabetes. Journal of Pakistan Medical Association; 1-8.

  • American Diabetes Association. Standards of Medical Care in Diabetes-2013. Diabetes Care . 2013; 36: 11-66.

  • U.S. Department Of Health And Human Services, National Institutes Of Health, National Heart, Lung, and Blood Institute. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. NIH 2003; 03-5233:3-86.

  • Raman R, Gupta A, Krishna S, Kulothungan V, Sharma T. Prevalence and risk factors for diabetic microvascular complications in newly diagnosed type II diabetes mellitus.Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study Journal of Diabetes and its Complication. 2012; 26: 123-8.

  • Sosale A, Kumar KMP, Sadikot SM, Nigam A, Bajaj S, Zargar AH, et al. Chronic Complications in Newly Diagnosed Patients with Type 2 Diabetes Mellitus in India. Indian Journal of Endocrinology and Metabolism. 2014; 18: 355-60.

  • Rani PK, Raman R, Rachapalli SR, Pal SS, Kulothungn V, Sharma T. Prevalence of Risk Factor for severity of diabetic neuropathy in Type 2 Diabetes Mellitus. Indian Journal of Endocrinology and Metabolism. 2010; 64:51-7.

  • Abbott CA, Chaturvedi N, Malik RA, Salgami E, Yates AP, Pemberton PW, et al. Explanations for the lower rates of diabetic neuropathy in Indian Asians versus Europeans. Diabetes Care .2010; 33:1325–30.

  • Spijkerman AMW, Dekker JM, Nijpels G, Kostense AMC, Ruwaard D, Stehouwer CDA, et al. Microvascular Complications at Time of Diagnosis of Type 2 Diabetes Are Similar Among Diabetic Patients Detected by Targeted Screening and Patients Newly Diagnosed in General Practice. Diabetes Care. 2003; 26: 2604-8.

  • Rema M, Ponnaiya M, Mohan V. Prevalence of retinopathy in non insulin dependent diabetes mellitus at a diabetes centre in southern India. Diabetes Res Clin Pract. 1996; 34:29–36.

  • Olivarius DFN, Nielsen NV, Andreasen AH. Diabetic retinopathy in newly diagnosed middle-aged and e lderlydiabetic patients: Prevalence a n d interrelationship with microalbuminuria and triglycerides. Graefes Arch Clin Exp Ophthalmol. 2001; 239:664–72.

  • Sosale A, Kumar KMP, Sadikot SM, Nigam A, Bajaj S, Zargar AH, et al. Chronic Complications in Newly Diagnosed Patients with Type 2 Diabetes Mellitus in India. Indian Journal of Endocrinology and Metabolism .2014; 18: 355-60.

  • Hillier TA, Pedula KL. Characteristics of an Adult Population with Newly Diagnosed Type 2 DiabetesThe relation of obesity and age of onset. Diabetes Care .2001; 24: 1522-7.

  • Hypertension in Dianetes Study (HDS):1. Prevalence of Hypertension in newly presenting type 2 Diabetic patients and the association with risk factors for cardiovascular and diabetic complications. J Hypertension .1993; 11: 309-10.

  • Raman R, Gupta A, Krishna S, Kulothungan V, Sharma T. Prevalence and risk factors for diabetic microvascular complications in newly diagnosed type II diabetes mellitus.Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study Journal of Diabetes and its Complication. 2012; 26: 123-8.

  • Agarwal N, Sengar NS, Jain PK, Khare R. Nephropathy in newly diagnosed type 2 diabetics with special stress on the role of hypertension. J Assoc Physicians India .2011; 59:145-7.

  • Bansal D, Gudala K, Esam HP, Nayakallu R, Vyamusani RV, Bhansali A. Microvascular Complications and Their Associated Risk Factors in Newly Diagnosed Type 2 Diabetes Mellitus Patients. International Journal of Chronic Diseases. 2014.

  • Abd A. Tahrani, Asad Ali, Neil T. Raymond, Safia Begum, Kiran Dubb, Shanaz Mugha, Biju Jose, Milan K. 5,6 Piya ,Anthony H. Barnett, Martin J. Stevens Obstructive Sleep Apnea and Diabetic NeuropathyA Novel Association in Patients with Type 2 Diabetes American Journal of Respiratory and Critical Care Medicine, 2012, 186, DOI: 10.1164/rccm.2011122135OC. and Critical Care Medicine, 2012, 186, DOI: 10.1164/rccm.201112-2135OC.


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  • Profile of Microvascular Complications in Newly Diagnosed Type 2 Diabetics and its Association with Correlates of Metabolic Syndrome in a Tertiary Hospital: An Observational Study

Abstract Views: 206  |  PDF Views: 57

Authors

Nikhitha Chandrashekar
M.S. Ramaiah Medical College, MSR College Road, MSR Nagar, MSRIT Post, Mathikere, Bengaluru - 560054, KA, India
Nivedita Maity
M.S. Ramaiah Medical College, MSR College Road, MSR Nagar, MSRIT Post, Mathikere, Bengaluru - 560054, KA, India
Pramila Kalra
M.S. Ramaiah Medical College, MSR College Road, MSR Nagar, MSRIT Post, Mathikere, Bengaluru - 560054, KA, India

Abstract


Aim: The primary objective was to study the profile of microvascular complications in newly diagnosed type 2 diabetics in a tertiary hospital and to determine its association with correlates of Metabolic Syndrome.

Settings and Design: This was a prospective observational study conducted over a period of six months among patients attending the Endocrinology outpatient of a tertiary care centre in a South Indian city.

Materials and Methods: We studied the correlation of microvascular complications (neuropathy, nephropathy, retinopathy and foot ulcers) in 44 newly diagnosed type 2 diabetics with associated risk factors i.e., hypertension, obesity and dyslipidemia.

Results: The prevalence of peripheral neuropathy, nephropathy and retinopathy was 15.9%, 2.3% and 2.3% respectively. The study showed that out of 44 patients, 18 had hypertension (40.91%). Four out of the 18 hypertensive patients had microvascular complications (22.2 %). There was a significant association between obesity and peripheral neuropathy (P< 0.05).

Conclusion: There was a maximum prevalence of peripheral neuropathy amongst the newly diagnosed diabetics thus they should be wary of the corresponding symptoms of numbness and tingling of feet. It was seen that out of the total 44 diabetic patients, 9.09% had both hypertension and microvascular complications. The low percentage is because 52% of the total hypertensives were on antihypertensive medication. There was also a significant association between obesity and neuropathy. Thus, those with obesity and hypertension are at a high risk of developing microvascular complications.


Keywords


Dyslipidemia, Obesity, Neuropathy, Metabolic Syndrome.

References