Journal of Ecophysiology and Occupational Health

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Efficacy of Vitamin E against Cigarette Smoke Induced Alterations in Pulmonary Tissue, Serum Enzymes and Lipid Profile in Albino Rats


Affiliations
1 Department of Environmental Studies, School of Life Sciences, Dr. B.R. Ambedkar University, Khandari Campus, Agra-282002, India
2 Department of Zoology, School of Life Sciences, Dr. B.R. Ambedkar University, Khandari Campus, Agra-282002, India
 

The present study was designed to evaluate the protective role of vitamin E(50mg/kg bwt) against adverse effects of cigarette smoke (60 and 120 days) on lung tissue , serum enzyme activity and lipid profile in male albino rats. Reduction in the histopathological changes like emphysema, pulmonary edema, debris, capillary permeability and thick epithelium have been seen after supplementation of vitamin E in comparison to cigarette smoke exposed rats. Decrease in serum enzyme activity viz. SGPT (P<0.05), SGOT (P>0.05) and SALP (P<0.05) and serum lipid profile-serum cholesterol (P>0.05), serum triglycerides (P<0.05), LDL (P>0.05) and VLDL (P<0.05) with corresponding increase in HDL level (P>0.05) have also reported after pre-exposure supplementation of vitamin E in comparison to cigarette smoke exposed rats. Vitamin E is able to mitigate the toxic effects of cigarette smoke on albino rats.

Keywords

Cigarette Smoke, Albino Rat, Lung Histopathology, SGPT, SGOT, SALP, Serum Lipid Profile, Antioxidant Vitamin E.
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  • Efficacy of Vitamin E against Cigarette Smoke Induced Alterations in Pulmonary Tissue, Serum Enzymes and Lipid Profile in Albino Rats

Abstract Views: 278  |  PDF Views: 127

Authors

B. S. Sharma
Department of Environmental Studies, School of Life Sciences, Dr. B.R. Ambedkar University, Khandari Campus, Agra-282002, India
Nibha Rathore
Department of Environmental Studies, School of Life Sciences, Dr. B.R. Ambedkar University, Khandari Campus, Agra-282002, India
Asha Agarwal
Department of Zoology, School of Life Sciences, Dr. B.R. Ambedkar University, Khandari Campus, Agra-282002, India

Abstract


The present study was designed to evaluate the protective role of vitamin E(50mg/kg bwt) against adverse effects of cigarette smoke (60 and 120 days) on lung tissue , serum enzyme activity and lipid profile in male albino rats. Reduction in the histopathological changes like emphysema, pulmonary edema, debris, capillary permeability and thick epithelium have been seen after supplementation of vitamin E in comparison to cigarette smoke exposed rats. Decrease in serum enzyme activity viz. SGPT (P<0.05), SGOT (P>0.05) and SALP (P<0.05) and serum lipid profile-serum cholesterol (P>0.05), serum triglycerides (P<0.05), LDL (P>0.05) and VLDL (P<0.05) with corresponding increase in HDL level (P>0.05) have also reported after pre-exposure supplementation of vitamin E in comparison to cigarette smoke exposed rats. Vitamin E is able to mitigate the toxic effects of cigarette smoke on albino rats.

Keywords


Cigarette Smoke, Albino Rat, Lung Histopathology, SGPT, SGOT, SALP, Serum Lipid Profile, Antioxidant Vitamin E.



DOI: https://doi.org/10.15512/joeoh%2F2012%2Fv12i1-2%2F92578