Possible Mechanisms for the Anti-Implantation Action of Dimethoate in Albino Mice

Dimethoate, an organopho-sphorus pesticide was administered orally to virgin pregnant mice at doses of 16,20,24 and 28mg/kg body weight/day for 7 consecutive days to examine its effect on blastocyst implantation. Control mice received similar quantities of distilled water. Autopsy on day 8 revealed that the distilled water treated mice were pregnant and had a normal number of implantations and normal duration of diestrus. Treatment with 16 and 20mg/kg/day diethoate neither inhibited implantation nor significantly changed diestrus.